ID   KC1A_RABIT              Reviewed;         325 AA.
AC   P67828; P35506;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   15-JUN-2010, entry version 48.
DE   RecName: Full=Casein kinase I isoform alpha;
DE            Short=CKI-alpha;
DE            EC=2.7.11.1;
DE   AltName: Full=CK1;
GN   Name=CSNK1A1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RA   Zhai L., DePaoli-Roach A.A., Roach P.J.;
RT   "Rabbit muscle casein kinase 1 alpha.";
RL   Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Casein kinases are operationally defined by their
CC       preferential utilization of acidic proteins such as caseins as
CC       substrates. It can phosphorylate a large number of proteins.
CC       Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'.
CC       May play a role in segregating chromosomes during mitosis (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Monomer. Interacts with the Axin complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm,
CC       cytoskeleton, centrosome (By similarity). Kinetochore (By
CC       similarity). Note=Localizes to the centrosome in interphase cells,
CC       and to kinetochore fibers during mitosis (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr
CC       protein kinase family. Casein kinase I subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U59166; AAB03992.1; -; mRNA.
DR   RefSeq; NP_001075842.1; -.
DR   UniGene; Ocu.2114; -.
DR   SMR; P67828; 10-302.
DR   Ensembl; ENSOCUT00000029447; ENSOCUP00000018081; ENSOCUG00000006669; Oryctolagus cuniculus.
DR   GeneID; 100009227; -.
DR   CTD; 100009227; -.
DR   eggNOG; maNOG09625; -.
DR   HOVERGEN; HBG000176; -.
DR   BRENDA; 2.7.11.1; 255.
DR   GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007067; P:mitosis; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_prot_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_prot_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ATP-binding; Cell cycle; Cell division; Cytoplasm;
KW   Cytoskeleton; Kinase; Kinetochore; Mitosis; Nucleotide-binding;
KW   Phosphoprotein; Serine/threonine-protein kinase; Transferase;
KW   Wnt signaling pathway.
FT   CHAIN         1    325       Casein kinase I isoform alpha.
FT                                /FTId=PRO_0000192825.
FT   DOMAIN       17    285       Protein kinase.
FT   NP_BIND      23     31       ATP (By similarity).
FT   ACT_SITE    136    136       Proton acceptor (By similarity).
FT   BINDING      46     46       ATP (By similarity).
FT   MOD_RES       3      3       Phosphoserine (By similarity).
FT   MOD_RES       8      8       N6-acetyllysine (By similarity).
FT   MOD_RES     105    105       Phosphoserine (By similarity).
FT   MOD_RES     311    311       Phosphoserine (By similarity).
FT   MOD_RES     313    313       Phosphoserine (By similarity).
FT   MOD_RES     321    321       Phosphothreonine (By similarity).
SQ   SEQUENCE   325 AA;  37567 MW;  B84DC84BDDC17854 CRC64;
     MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE
     SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM
     ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN
     LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK
     MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM
     LKQKAAQQAA SSSGQGQQAQ TPTGF
//