Casein kinase I isoform alpha - CSNK1A1 - Oryctolagus cuniculus (Rabbit)

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P67828 (KC1A_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Casein kinase I isoform alpha
Short name=CKI-alpha
EC=2.7.11.1

Alternative name(s):
CK1

Gene names

Name:

CSNK1A1

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome By similarity. Chromosome › centromere › kinetochore By similarity. Nucleus speckle By similarity. Note: Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Wnt signaling pathway
Cellular component	Centromere Chromosome Cytoplasm Cytoskeleton Kinetochore Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW cell morphogenesis Inferred from electronic annotation. Source: Ensembl mitosis Inferred from electronic annotation. Source: UniProtKB-KW protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear speck Inferred from sequence or structural similarity. Source: UniProtKB ribonucleoprotein complex Inferred from electronic annotation. Source: Ensembl
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAB	P31946	3	EBI-7540603,EBI-359815	From a different organism.
Ywhae	P62260	2	EBI-7540603,EBI-356462	From a different organism.
YWHAG	P61981	3	EBI-7540603,EBI-359832	From a different organism.
YWHAH	Q04917	8	EBI-7540603,EBI-306940	From a different organism.
YWHAQ	P27348	2	EBI-7540603,EBI-359854	From a different organism.
YWHAZ	P63104	4	EBI-7540603,EBI-347088	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 325

324

Casein kinase I isoform alpha

PRO_0000192825

Regions

Domain

17 – 285

269

Protein kinase

Nucleotide binding

23 – 31

ATP By similarity

Sites

Active site

136

Proton acceptor By similarity

Binding site

ATP By similarity

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

N6-acetyllysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P67828 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: B84DC84BDDC17854
Show »

FASTA

325

37,567

        10         20         30         40         50         60 
MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE 

        70         80         90        100        110        120 
SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM 

       130        140        150        160        170        180 
ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN 

       190        200        210        220        230        240 
LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK 

       250        260        270        280        290        300 
MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM 

       310        320 
LKQKAAQQAA SSSGQGQQAQ TPTGF

« Hide

References

[1]	"Rabbit muscle casein kinase 1 alpha." Zhai L., DePaoli-Roach A.A., Roach P.J. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59166 mRNA. Translation: AAB03992.1.
RefSeq	NP_001075842.1. NM_001082373.1.
UniGene	Ocu.2114.
3D structure databases
ProteinModelPortal	P67828.
SMR	P67828. Positions 17-302.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
IntAct	P67828. 9 interactions.
MINT	MINT-7264083.
Chemistry
BindingDB	P67828.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSOCUT00000029447; ENSOCUP00000018081; ENSOCUG00000006669.
GeneID	100009227.
Organism-specific databases
CTD	1452.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00730000110518.
HOGENOM	HOG000182055.
HOVERGEN	HBG000176.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. SSF56112. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806353.

Entry information

Entry name

KC1A_RABIT

Accession

Primary (citable) accession number: P67828
Secondary accession number(s): P35506

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents