UniProtKB - P67828 (KC1A_RABIT)
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Protein
Casein kinase I isoform alpha
Gene
CSNK1A1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration.By similarity
Catalytic activityi
ATP + a protein = ADP + a phosphoprotein.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 46 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 136 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 23 – 31 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cell morphogenesis Source: Ensembl
- Golgi organization Source: Ensembl
- intermediate filament cytoskeleton organization Source: UniProtKB
- peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
- protein phosphorylation Source: UniProtKB
- regulation of GTP binding Source: Ensembl
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division, Mitosis, Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase I isoform alpha (EC:2.7.11.1)Short name: CKI-alpha Alternative name(s): CK1 |
Gene namesi | Name:CSNK1A1 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
Cell projection, Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000192825 | 2 – 325 | Casein kinase I isoform alphaAdd BLAST | 324 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 4 | PhosphoserineBy similarity | 1 | |
Modified residuei | 8 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinInteractioni
Subunit structurei
Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. Interacts with FAM83H; recruits CSNK1A1 to keratin filaments.By similarity
Binary interactionsi
Protein-protein interaction databases
IntActi | P67828. 9 interactors. |
MINTi | P67828. |
Structurei
3D structure databases
ProteinModelPortali | P67828. |
SMRi | P67828. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 285 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 269 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Curated
Phylogenomic databases
GeneTreei | ENSGT00760000119040. |
HOGENOMi | HOG000182055. |
HOVERGENi | HBG000176. |
InParanoidi | P67828. |
KOi | K08957. |
OMAi | GPDYMYL. |
OrthoDBi | EOG091G0AFG. |
Family and domain databases
InterProi | View protein in InterPro IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. |
Pfami | View protein in Pfam PF00069. Pkinase. 1 hit. |
SMARTi | View protein in SMART SM00220. S_TKc. 1 hit. |
SUPFAMi | SSF56112. SSF56112. 1 hit. |
PROSITEi | View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P67828-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ
60 70 80 90 100
KARHPQLLYE SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL
110 120 130 140 150
FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC
160 170 180 190 200
NKLFLIDFGL AKKYRDNRTR QHIPYREDKN LTGTARYASI NAHLGIEQSR
210 220 230 240 250
RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK MSTPVEVLCK
260 270 280 290 300
GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM
310 320
LKQKAAQQAA SSSGQGQQAQ TPTGF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59166 mRNA. Translation: AAB03992.1. |
RefSeqi | NP_001075842.1. NM_001082373.1. |
UniGenei | Ocu.2114. |
Genome annotation databases
Ensembli | ENSOCUT00000029447; ENSOCUP00000018081; ENSOCUG00000006669. |
GeneIDi | 100009227. |
KEGGi | ocu:100009227. |
Similar proteinsi
Entry informationi
Entry namei | KC1A_RABIT | |
Accessioni | P67828Primary (citable) accession number: P67828 Secondary accession number(s): P35506 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 28, 2018 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |