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Protein

Copper homeostasis protein CutC

Gene

cutC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates in the control of copper homeostasis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular copper ion homeostasis Source: EcoliWiki
  • copper ion homeostasis Source: EcoliWiki
  • response to copper ion Source: EcoliWiki

Keywordsi

LigandCopper

Enzyme and pathway databases

BioCyciEcoCyc:G7024-MONOMER

Protein family/group databases

TCDBi9.B.158.1.2 the cut copper homeostasis (cut) family

Names & Taxonomyi

Protein namesi
Recommended name:
Copper homeostasis protein CutCUniRule annotation
Gene namesi
Name:cutC1 PublicationUniRule annotation
Synonyms:cutCM
Ordered Locus Names:b1874, JW1863
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12956 cutC

Subcellular locationi

  • Cytoplasm UniRule annotationCurated

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

CutC-nlpE double mutants show increased copper sensitivity (PubMed:7635807). However, the copper sensitivity phenotype of the mutant was later shown to be due to the loss of MicL sRNA and elevated Lpp levels (PubMed:25030700).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150641 – 248Copper homeostasis protein CutCAdd BLAST248

Proteomic databases

PaxDbiP67826
PRIDEiP67826

Interactioni

Subunit structurei

Homodimer.UniRule annotationBy similarity

Protein-protein interaction databases

BioGridi4262958, 15 interactors
IntActiP67826, 6 interactors
STRINGi316385.ECDH10B_2015

Structurei

3D structure databases

ProteinModelPortaliP67826
SMRiP67826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CutC family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4106N3A Bacteria
COG3142 LUCA
HOGENOMiHOG000100908
InParanoidiP67826
KOiK06201
OMAiRIIIMPG
PhylomeDBiP67826

Family and domain databases

Gene3Di3.20.20.380, 1 hit
HAMAPiMF_00795 CutC, 1 hit
InterProiView protein in InterPro
IPR005627 Cu_homeostasis_CutC
IPR023648 Cu_homeostasis_CutC_dom
IPR036822 CutC_dom_sf
PANTHERiPTHR12598 PTHR12598, 1 hit
PfamiView protein in Pfam
PF03932 CutC, 1 hit
SUPFAMiSSF110395 SSF110395, 1 hit

Sequencei

Sequence statusi: Complete.

P67826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLEICCYS MECALTAQQN GADRVELCAA PKEGGLTPSL GVLKSVRQRV
60 70 80 90 100
TIPVHPIIRP RGGDFCYSDG EFAAILEDVR TVRELGFPGL VTGVLDVDGN
110 120 130 140 150
VDMPRMEKIM AAAGPLAVTF HRAFDMCANP LYTLNNLAEL GIARVLTSGQ
160 170 180 190 200
KSDALQGLSK IMELIAHRDA PIIMAGAGVR AENLHHFLDA GVLEVHSSAG
210 220 230 240
AWQASPMRYR NQGLSMSSDE HADEYSRYIV DGAAVAEMKG IIERHQAK
Length:248
Mass (Da):26,762
Last modified:October 11, 2004 - v1
Checksum:i998A55A417A010B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18Q → H in AAA89202 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38618 Genomic DNA Translation: AAA89202.1
U00096 Genomic DNA Translation: AAC74944.2
AP009048 Genomic DNA Translation: BAA15684.1
PIRiB64950
RefSeqiWP_001185741.1, NZ_LN832404.1
YP_025309.2, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC74944; AAC74944; b1874
BAA15684; BAA15684; BAA15684
GeneIDi2847756
KEGGiecj:JW1863
eco:b1874
PATRICifig|1411691.4.peg.374

Similar proteinsi

Entry informationi

Entry nameiCUTC_ECOLI
AccessioniPrimary (citable) accession number: P67826
Secondary accession number(s): P46719, P76294
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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