P67812 (SC11A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Signal peptidase complex catalytic subunit SEC11A
EC=3.4.21.89

Alternative name(s):
Endopeptidase SP18
Microsomal signal peptidase 18 kDa subunit
Short name=SPase 18 kDa subunit
SEC11 homolog A
SEC11-like protein 1
SPC18

Gene names

Name:	SEC11A
Synonyms:	SEC11L1, SPC18, SPCS4A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum By similarity.
Catalytic activity	Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
Subunit structure	Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3 By similarity.
Subcellular location	Microsome membrane; Single-pass type II membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the peptidase S26B family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome proteolysis Inferred from electronic annotation. Source: UniProtKB-KW regulation of insulin secretion Traceable author statement. Source: Reactome signal peptide processing Inferred from electronic annotation. Source: InterPro small molecule metabolic process Traceable author statement. Source: Reactome translation Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	serine-type peptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Signal peptidase complex catalytic subunit SEC11A		PRO_0000109543
Regions
	Topological domain	1 – 16	16	Cytoplasmic Potential
	Transmembrane	17 – 36	20	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	37 – 179	143	Lumenal Potential
Sites
	Active site	56	1	By similarity
Experimental info
	Sequence conflict	19	1	Y → C in AAD19640. Ref.1
	Sequence conflict	19	1	Y → C in AAC36354. Ref.6
	Sequence conflict	42	1	I → T in BAD96944. Ref.4
	Sequence conflict	163	1	K → R in AAD19640. Ref.1
	Sequence conflict	163	1	K → R in AAC36354. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P67812 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: DFD245A17BA3B47F	FASTA	179	20,625
	10 20 30 40 50 60 MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM VITGSESPIV VVLSGSMEPA 70 80 90 100 110 120 FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK IHEKQNGHIK FLTKGDNNAV 130 140 150 160 170 DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG IVTILMNDYP KFKYAVLFLL GLFVLVHRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human signal peptidase 18 kDa subunit, mRNA complete cds." Xie T.P., Wu M.C., Liu X.P., Wang H.J., Liang Y., Guo Y.J. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hepatoma.
[2]	"Human microsomal signal peptidase." Zhang J., Mao M., Liu T., Wu J., Zhang Q., Fu G., Shen Y., Zhou J., Yu Y., Wang Z., Chen S., Chen Z. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastric mucosa.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Muscle.
[7]	Xie T.P., Liu X.P., Wang H.J., Liang Y., Wang H., Qian W.Z., Wei L.X., Liu Y.J., He P., Guo Y.J. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-179. Tissue: Hepatoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF108945 mRNA. Translation: AAD19640.1. AF061737 mRNA. Translation: AAD17526.1. AK223224 mRNA. Translation: BAD96944.1. AK314146 mRNA. Translation: BAG36834.1. CH471101 Genomic DNA. Translation: EAX01954.1. BC000359 mRNA. Translation: AAH00359.3. BC014508 mRNA. Translation: AAH14508.1. AF090315 mRNA. Translation: AAC36354.1.
IPI	IPI00104128.
RefSeq	NP_001258847.1. NM_001271918.1. NP_001258848.1. NM_001271919.1. NP_001258849.1. NM_001271920.1. NP_001258850.1. NM_001271921.1. NP_001258851.1. NM_001271922.1. NP_055115.1. NM_014300.3.
UniGene	Hs.9534.
3D structure databases
ProteinModelPortal	P67812.
SMR	P67812. Positions 47-146.
ModBase	Search...
Protein-protein interaction databases
IntAct	P67812. 2 interactions.
MINT	MINT-1387363.
STRING	9606.ENSP00000268220.
Protein family/group databases
MEROPS	S26.009.
PTM databases
PhosphoSite	P67812.
Polymorphism databases
DMDM	54039634.
Proteomic databases
PaxDb	P67812.
PRIDE	P67812.
Protocols and materials databases
DNASU	23478.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268220; ENSP00000268220; ENSG00000140612.
GeneID	23478.
KEGG	hsa:23478.
UCSC	uc002blb.1. human.
Organism-specific databases
CTD	23478.
GeneCards	GC15M085212.
HGNC	HGNC:17718. SEC11A.
neXtProt	NX_P67812.
PharmGKB	PA162402586.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0681.
HOGENOM	HOG000111516.
HOVERGEN	HBG057279.
InParanoid	P67812.
KO	K13280.
OMA	ITIYMNE.
OrthoDB	EOG4ZPDW9.
PhylomeDB	P67812.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P67812.
Bgee	P67812.
CleanEx	HS_SEC11A.
Genevestigator	P67812.
GermOnline	ENSG00000140612. Homo sapiens.
Family and domain databases
Gene3D	2.10.109.10. 1 hit.
InterPro	IPR019758. Pept_S26A_signal_pept_1_CS. IPR019756. Pept_S26A_signal_pept_1_Ser-AS. IPR019759. Peptidase_S24_S26. IPR015927. Peptidase_S24_S26A/B/C. IPR011056. Peptidase_S24_S26A/B/C_b-rbn. IPR001733. Peptidase_S26B. [Graphical view]
PANTHER	PTHR10806. PTHR10806. 1 hit.
Pfam	PF00717. Peptidase_S24. 1 hit. [Graphical view]
PRINTS	PR00728. SIGNALPTASE.
SUPFAM	SSF51306. Pept_S24_S26_C. 1 hit.
TIGRFAMs	TIGR02228. sigpep_I_arch. 1 hit.
PROSITE	PS00501. SPASE_I_1. 1 hit. PS00761. SPASE_I_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SEC11A. human.
GenomeRNAi	23478.
NextBio	45823.

Entry information

Entry name

SC11A_HUMAN

Accession

Primary (citable) accession number: P67812
Secondary accession number(s): B2RAD7 , O75957, P21378, Q53FQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.