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Protein

Signal peptidase complex catalytic subunit SEC11A

Gene

SEC11A

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.1 Publication

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

ReactomeiR-CFA-422085 Synthesis, secretion, and deacylation of Ghrelin

Protein family/group databases

MEROPSiS26.009

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11A (EC:3.4.21.89)
Alternative name(s):
Endopeptidase SP18
Microsomal signal peptidase 18 kDa subunit
Short name:
SPase 18 kDa subunit
SEC11 homolog A
SEC11-like protein 1
SPC18
Gene namesi
Name:SEC11A
Synonyms:SEC11L1, SPC18
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:53239 SEC11A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 36Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini37 – 179LumenalSequence analysisAdd BLAST143

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095421 – 179Signal peptidase complex catalytic subunit SEC11AAdd BLAST179

Proteomic databases

PaxDbiP67811
PRIDEiP67811

Expressioni

Gene expression databases

BgeeiENSCAFG00000012889

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

Protein-protein interaction databases

CORUMiP67811
STRINGi9615.ENSCAFP00000018993

Structurei

3D structure databases

ProteinModelPortaliP67811
SMRiP67811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00390000015600
HOGENOMiHOG000111516
HOVERGENiHBG057279
InParanoidiP67811
KOiK13280
OMAiYIPFVGY
OrthoDBiEOG091G0X3D
TreeFamiTF313648

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
IPR037712 SEC11A/SEC11B
PANTHERiPTHR10806 PTHR10806, 1 hit
PTHR10806:SF8 PTHR10806:SF8, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

P67811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM VITGSESPIV
60 70 80 90 100
VVLSGSMEPA FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK
110 120 130 140 150
IHEKQNGHIK FLTKGDNNAV DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG
160 170
IVTILMNDYP KFKYAVLFLL GLFVLVHRE
Length:179
Mass (Da):20,625
Last modified:October 11, 2004 - v1
Checksum:iDFD245A17BA3B47F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05466 mRNA Translation: AAA30895.1
PIRiA35309
RefSeqiNP_001003313.1, NM_001003313.1
UniGeneiCfa.3874

Genome annotation databases

EnsembliENSCAFT00000020466; ENSCAFP00000018993; ENSCAFG00000012889
GeneIDi404004
KEGGicfa:404004

Entry informationi

Entry nameiSC11A_CANLF
AccessioniPrimary (citable) accession number: P67811
Secondary accession number(s): O75957, P21378
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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