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Protein

Signal peptidase complex catalytic subunit SEC11A

Gene

SEC11A

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.1 Publication

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Protein family/group databases

MEROPSiS26.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11A (EC:3.4.21.89)
Alternative name(s):
Endopeptidase SP18
Microsomal signal peptidase 18 kDa subunit
Short name:
SPase 18 kDa subunit
SEC11 homolog A
SEC11-like protein 1
SPC18
Gene namesi
Name:SEC11A
Synonyms:SEC11L1, SPC18
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3620Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini37 – 179143LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Signal peptidase complex catalytic subunit SEC11APRO_0000109542Add
BLAST

Proteomic databases

PaxDbiP67811.
PRIDEiP67811.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000018993.

Structurei

3D structure databases

ProteinModelPortaliP67811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP67811.
KOiK13280.
OMAiGQLWLEK.
OrthoDBiEOG7V4B0P.
TreeFamiTF313648.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P67811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM VITGSESPIV
60 70 80 90 100
VVLSGSMEPA FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK
110 120 130 140 150
IHEKQNGHIK FLTKGDNNAV DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG
160 170
IVTILMNDYP KFKYAVLFLL GLFVLVHRE
Length:179
Mass (Da):20,625
Last modified:October 11, 2004 - v1
Checksum:iDFD245A17BA3B47F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05466 mRNA. Translation: AAA30895.1.
PIRiA35309.
RefSeqiNP_001003313.1. NM_001003313.1.
UniGeneiCfa.3874.

Genome annotation databases

EnsembliENSCAFT00000020466; ENSCAFP00000018993; ENSCAFG00000012889.
GeneIDi404004.
KEGGicfa:404004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05466 mRNA. Translation: AAA30895.1.
PIRiA35309.
RefSeqiNP_001003313.1. NM_001003313.1.
UniGeneiCfa.3874.

3D structure databases

ProteinModelPortaliP67811.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000018993.

Protein family/group databases

MEROPSiS26.009.

Proteomic databases

PaxDbiP67811.
PRIDEiP67811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000020466; ENSCAFP00000018993; ENSCAFG00000012889.
GeneIDi404004.
KEGGicfa:404004.

Organism-specific databases

CTDi23478.

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP67811.
KOiK13280.
OMAiGQLWLEK.
OrthoDBiEOG7V4B0P.
TreeFamiTF313648.

Enzyme and pathway databases

ReactomeiR-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein."
    Shelness G.S., Blobel G.
    J. Biol. Chem. 265:9512-9519(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-34.
    Tissue: Liver.
  2. "Purification of microsomal signal peptidase as a complex."
    Evans E.A., Gilmore R., Blobel G.
    Proc. Natl. Acad. Sci. U.S.A. 83:581-585(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF SIGNAL PEPTIDASE COMPLEX.
  3. "Membrane topology and biogenesis of eukaryotic signal peptidase."
    Shelness G.S., Lin L., Nicchitta C.V.
    J. Biol. Chem. 268:5201-5208(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
  4. "Genetic complementation in yeast reveals functional similarities between the catalytic subunits of mammalian signal peptidase complex."
    Liang H., VanValkenburgh C., Chen X., Mullins C., Van Kaer L., Green N., Fang H.
    J. Biol. Chem. 278:50932-50939(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSC11A_CANLF
AccessioniPrimary (citable) accession number: P67811
Secondary accession number(s): O75957, P21378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.