P67807 (A70A_DROSI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Accessory gland-specific peptide 70A

Alternative name(s):
Paragonial peptide B
Sex peptide
Short name=SP

Gene names

Name:	Acp70A
Synonyms:	AcpA, PAPB
ORF Names:	GD14439

Organism

Drosophila simulans (Fruit fly) [Complete proteome]

Taxonomic identifier

7240 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	55 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Represses female sexual receptivity and stimulates oviposition.
Subcellular location	Secreted.
Tissue specificity	Main cells of the accessory glands of males (paragonial gland).

Ontologies

Keywords
Biological process	Behavior
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Hydroxylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of female receptivity, post-mating Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 55	36	Accessory gland-specific peptide 70A		PRO_0000020589
Amino acid modifications
	Modified residue	28	1	Hydroxyproline By similarity
	Modified residue	32	1	Hydroxyproline By similarity
	Modified residue	34	1	Hydroxyproline By similarity
	Modified residue	38	1	Hydroxyproline By similarity
	Disulfide bond	43 ↔ 55		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P67807 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E87397C3F196123D	FASTA	55	6,424
	10 20 30 40 50 MKTLSLFLVL VCLLGLVQSW EWPWNRKPTK YPIPSPNPRD KWCRLNLGPA WGGRC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary history of the sex-peptide (Acp70A) gene region in Drosophila melanogaster." Cirera S., Aguade M.N. Genetics 147:189-197(1997) [PubMed: 9286679] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila." Halligan D.L., Eyre-Walker A., Andolfatto P., Keightley P.D. Genome Res. 14:273-279(2004) [PubMed: 14762063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99417 Genomic DNA. Translation: CAA67794.1. CM000363 Genomic DNA. Translation: EDX10339.1. AY459566 Genomic DNA. Translation: AAR23020.1.
RefSeq	XP_002084754.1. XM_002084718.1.
UniGene	Dsi.2878.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0214349; FBpp0212841; FBgn0021129.
GeneID	6737935.
KEGG	dsi:Dsim_GD14439.
Organism-specific databases
FlyBase	FBgn0021129. Dsim\Acp70A.
Phylogenomic databases
GeneTree	EMGT00050000023299.
OrthoDB	EOG40K6GQ.
PhylomeDB	P67807.
Family and domain databases
InterPro	IPR012608. Sex_peptide. [Graphical view]
Pfam	PF08138. Sex_peptide. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A70A_DROSI

Accession

Primary (citable) accession number: P67807
Secondary accession number(s): B4QJ08, O18666, Q6SE45

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project