SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P67805

- GSTT1_DROSI

UniProt

P67805 - GSTT1_DROSI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutathione S-transferase 1-1
Gene
GstD1, gst, GST1, GD20577
Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Glutathione By similarity

GO - Molecular functioni

  1. DDT-dehydrochlorinase activity Source: UniProtKB-EC
  2. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1-1 (EC:2.5.1.18, EC:4.5.1.1)
Alternative name(s):
DDT-dehydrochlorinase
GST class-theta
Gene namesi
Name:GstD1
Synonyms:gst, GST1
ORF Names:GD20577
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 3R, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012838. Dsim\GstD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Glutathione S-transferase 1-1
PRO_0000185951Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP67805.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8181GST N-terminal
Add
BLAST
Domaini87 – 209123GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 533Glutathione binding By similarity
Regioni65 – 673Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.

Phylogenomic databases

KOiK00799.
OrthoDBiEOG7V1FRJ.
PhylomeDBiP67805.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P67805-1 [UniParc]FASTAAdd to Basket

« Hide

MADFYYLPGS SPCRSVIMTA KAVGVELNKK LLNLQAGEHL KPEFLKINPQ    50
HTIPTLVDNG FALWESRAIQ VYLVEKYGKT DSLYPKCPKK RAVINQRLYF 100
DMGTLYQSFA NYYYPQVFAK APADPEAFKK IESAFEFLNT FLEGQEYAAG 150
DSLTVADIAL VASVSTFEVA GFEISKYANV NKWYENAKKV TPGWEENWAG 200
CLEFKKYFE 209
Length:209
Mass (Da):23,755
Last modified:February 22, 2012 - v2
Checksum:iE1FED3D6423D9B1A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → V in AAK66764. 1 Publication
Sequence conflicti195 – 1951E → S in M84577. 1 Publication
Sequence conflicti207 – 2071Y → F in M84577. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF386788 mRNA. Translation: AAK66764.1.
CM000364 Genomic DNA. Translation: EDX13236.1.
M84577 Genomic DNA. No translation available.
RefSeqiXP_002103733.1. XM_002103697.1.
UniGeneiDsi.689.

Genome annotation databases

EnsemblMetazoaiFBtr0220487; FBpp0218979; FBgn0012838.
GeneIDi6728385.
KEGGidsi:Dsim_GD20577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF386788 mRNA. Translation: AAK66764.1 .
CM000364 Genomic DNA. Translation: EDX13236.1 .
M84577 Genomic DNA. No translation available.
RefSeqi XP_002103733.1. XM_002103697.1.
UniGenei Dsi.689.

3D structure databases

ProteinModelPortali P67805.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0220487 ; FBpp0218979 ; FBgn0012838 .
GeneIDi 6728385.
KEGGi dsi:Dsim_GD20577.

Organism-specific databases

FlyBasei FBgn0012838. Dsim\GstD1.

Phylogenomic databases

KOi K00799.
OrthoDBi EOG7V1FRJ.
PhylomeDBi P67805.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the Drosophila simulans glutathione S-transferase D1."
    Le Goff G., Berge J.-B., Amichot M.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila."
    Hargis M.T., Cochrane B.J.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-208.

Entry informationi

Entry nameiGSTT1_DROSI
AccessioniPrimary (citable) accession number: P67805
Secondary accession number(s): B4QSX6, P30105, Q963F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 22, 2012
Last modified: July 9, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi