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P67793

- COX1_CHOOC

UniProt

P67793 - COX1_CHOOC

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Choristoneura occidentalis (Western spruce budworm)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Iron (heme A axial ligand)Curated
    Metal bindingi239 – 2391Copper BCurated
    Metal bindingi243 – 2431Copper BCurated
    Metal bindingi289 – 2891Copper BCurated
    Metal bindingi290 – 2901Copper BCurated
    Metal bindingi375 – 3751Iron (heme A3 axial ligand)Curated
    Metal bindingi377 – 3771Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiChoristoneura occidentalis (Western spruce budworm)
    Taxonomic identifieri27541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaTortricoideaTortricidaeTortricinaeChoristoneura

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Cytochrome c oxidase subunit 1PRO_0000183310Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP67793.
    SMRiP67793. Positions 2-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei384 – 40421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei451 – 47121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P67793-1 [UniParc]FASTAAdd to Basket

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    MMRKWLYSTN HKDIGTLYFM FGIWAGMVGT SLSLLIRAEL GNPGSLIGDD    50
    QIYNTIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS 100
    FWLLPPSIML LISSSIVENG AGTGWTVYPP LSSNIAHSGS SVDLAIFSLH 150
    LAGISSILGA VNFITTIINM RPNNMSLDQM PLFVWSVGIT ALLLLLSLPV 200
    LAGAITMLLT DRNLNTSFFD PAGGGDPILY QHLFWFFGHP EVYILILPGF 250
    GMISHIISQE SGKKETFGCL GMIYAMMAIG LLGFVVWAHH MFTVGMDIDT 300
    RAYFTSATMI IAVPTGIKIF SWLATLHGTQ INYSPSMLWS LGFVFLFTVG 350
    GLTGVILANS SIDVTLHDTY YVVAHFHYVL SMGAVFAIMG GFVHWYPLFT 400
    GLALNPYLLK IQFFTMFIGV NLTFFPQHFL GLAGMPRRYS DYPDTYTSWN 450
    IISSLGSYIS LVATMLMLMI IWESLINKRI ILFPLNMNSS IEWYQNLPPA 500
    EHSYNELPIL SNF 513
    Length:513
    Mass (Da):57,033
    Last modified:October 3, 2006 - v2
    Checksum:iEE6CE6916D9399A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19094 Genomic DNA. Translation: AAA53646.3.
    L19097 Genomic DNA. Translation: AAA53642.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19094 Genomic DNA. Translation: AAA53646.3 .
    L19097 Genomic DNA. Translation: AAA53642.1 .

    3D structure databases

    ProteinModelPortali P67793.
    SMRi P67793. Positions 2-506.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Roe A., Sperling F.A.H.
      Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 462.
    2. "Mitochondrial DNA sequence variation in the spruce budworm species complex (Choristoneura: Lepidoptera)."
      Sperling F.A.H., Hickey D.A.
      Mol. Biol. Evol. 11:656-665(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 240-513.
      Strain: Isolate 16.

    Entry informationi

    Entry nameiCOX1_CHOOC
    AccessioniPrimary (citable) accession number: P67793
    Secondary accession number(s): P50670
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3