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Protein

Prohibitin

Gene

Phb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

GO - Molecular functioni

GO - Biological processi

  • DNA biosynthetic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • organ regeneration Source: RGD
  • ovarian follicle atresia Source: RGD
  • ovarian follicle development Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to immobilization stress Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Biological processi

DNA synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin
Gene namesi
Name:Phb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3322. Phb.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: Ensembl
  • cytoplasm Source: RGD
  • extrinsic component of mitochondrial outer membrane Source: RGD
  • mitochondrial crista Source: RGD
  • mitochondrion Source: RGD
  • myelin sheath Source: Ensembl
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 272271ProhibitinPRO_0000213880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei91 – 911PhosphothreonineBy similarity
Modified residuei128 – 1281N6-acetyllysineBy similarity
Modified residuei186 – 1861N6-acetyllysineBy similarity
Modified residuei202 – 2021N6-acetyllysine; alternateBy similarity
Modified residuei202 – 2021N6-succinyllysine; alternateBy similarity
Modified residuei249 – 2491PhosphotyrosineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP67779.
PRIDEiP67779.

2D gel databases

World-2DPAGE0004:P67779.

PTM databases

iPTMnetiP67779.
PhosphoSiteiP67779.

Expressioni

Tissue specificityi

Expressed in brain, heart, intestine, kidney, liver, skeletal muscle. Highest levels in heart, liver, kidney and intestine. Also expressed in flagella of epididymal sperm.2 Publications

Developmental stagei

Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas.1 Publication

Gene expression databases

BgeeiENSRNOG00000046799.
GenevisibleiP67779. RN.

Interactioni

Subunit structurei

Interacts with PHB2. Interacts with STOML2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi247383. 1 interaction.
IntActiP67779. 1 interaction.
STRINGi10116.ENSRNOP00000066502.

Structurei

3D structure databases

ProteinModelPortaliP67779.
SMRiP67779. Positions 60-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili177 – 21135Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3083. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074770.
HOVERGENiHBG004457.
InParanoidiP67779.
KOiK17080.
OMAiTMANEKQ.
OrthoDBiEOG091G0IHW.
PhylomeDBiP67779.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV
60 70 80 90 100
GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA
110 120 130 140 150
SQLPRIYTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV
160 170 180 190 200
SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV
210 220 230 240 250
EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ
260 270
LSRSRNITYL PAGQSVLLQL PQ
Length:272
Mass (Da):29,820
Last modified:October 11, 2004 - v1
Checksum:i6B26073E169C2FFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61219 mRNA. Translation: AAA63500.1.
BC072518 mRNA. Translation: AAH72518.1.
BC097304 mRNA. Translation: AAH97304.1.
PIRiA39682.
RefSeqiNP_114039.1. NM_031851.2.
UniGeneiRn.29754.

Genome annotation databases

EnsembliENSRNOT00000075733; ENSRNOP00000066502; ENSRNOG00000046799.
GeneIDi25344.
KEGGirno:25344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61219 mRNA. Translation: AAA63500.1.
BC072518 mRNA. Translation: AAH72518.1.
BC097304 mRNA. Translation: AAH97304.1.
PIRiA39682.
RefSeqiNP_114039.1. NM_031851.2.
UniGeneiRn.29754.

3D structure databases

ProteinModelPortaliP67779.
SMRiP67779. Positions 60-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247383. 1 interaction.
IntActiP67779. 1 interaction.
STRINGi10116.ENSRNOP00000066502.

PTM databases

iPTMnetiP67779.
PhosphoSiteiP67779.

2D gel databases

World-2DPAGE0004:P67779.

Proteomic databases

PaxDbiP67779.
PRIDEiP67779.

Protocols and materials databases

DNASUi25344.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075733; ENSRNOP00000066502; ENSRNOG00000046799.
GeneIDi25344.
KEGGirno:25344.

Organism-specific databases

CTDi5245.
RGDi3322. Phb.

Phylogenomic databases

eggNOGiKOG3083. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074770.
HOVERGENiHBG004457.
InParanoidiP67779.
KOiK17080.
OMAiTMANEKQ.
OrthoDBiEOG091G0IHW.
PhylomeDBiP67779.

Miscellaneous databases

PROiP67779.

Gene expression databases

BgeeiENSRNOG00000046799.
GenevisibleiP67779. RN.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHB_RAT
AccessioniPrimary (citable) accession number: P67779
Secondary accession number(s): P24142, Q4V8M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.