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Protein

Prohibitin

Gene

Phb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA synthesis

Enzyme and pathway databases

ReactomeiR-MMU-5673000. RAF activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin
Alternative name(s):
B-cell receptor-associated protein 32
Short name:
BAP 32
Gene namesi
Name:Phb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97572. Phb.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytoplasm Source: MGI
  • early endosome Source: MGI
  • extracellular exosome Source: MGI
  • extrinsic component of mitochondrial outer membrane Source: Ensembl
  • integral component of plasma membrane Source: MGI
  • membrane Source: MGI
  • mitochondrial crista Source: Ensembl
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • myelin sheath Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002138792 – 272ProhibitinAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei91PhosphothreonineBy similarity1
Modified residuei128N6-acetyllysineCombined sources1
Modified residuei186N6-acetyllysineCombined sources1
Modified residuei202N6-acetyllysine; alternateCombined sources1
Modified residuei202N6-succinyllysine; alternateCombined sources1
Modified residuei249PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP67778.
MaxQBiP67778.
PaxDbiP67778.
PeptideAtlasiP67778.
PRIDEiP67778.
TopDownProteomicsiP67778.

2D gel databases

REPRODUCTION-2DPAGEIPI00133440.
P67778.
SWISS-2DPAGEP67778.

PTM databases

iPTMnetiP67778.
PhosphoSitePlusiP67778.
SwissPalmiP67778.

Expressioni

Tissue specificityi

Widely expressed in different tissues.1 Publication

Developmental stagei

Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000038845.
CleanExiMM_PHB.
ExpressionAtlasiP67778. baseline and differential.
GenevisibleiP67778. MM.

Interactioni

Subunit structurei

Interacts with PHB2. Interacts with STOML2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Rab32Q9CZE34EBI-298507,EBI-11566047

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202141. 2 interactors.
IntActiP67778. 12 interactors.
MINTiMINT-1841697.
STRINGi10090.ENSMUSP00000119603.

Structurei

3D structure databases

ProteinModelPortaliP67778.
SMRiP67778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili177 – 211Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3083. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074770.
HOGENOMiHOG000205692.
HOVERGENiHBG004457.
InParanoidiP67778.
KOiK17080.
OMAiTMANEKQ.
OrthoDBiEOG091G0IHW.
TreeFamiTF300095.

Family and domain databases

CDDicd03401. SPFH_prohibitin. 1 hit.
InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV
60 70 80 90 100
GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA
110 120 130 140 150
SQLPRIYTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV
160 170 180 190 200
SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV
210 220 230 240 250
EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ
260 270
LSRSRNITYL PAGQSVLLQL PQ
Length:272
Mass (Da):29,820
Last modified:October 11, 2004 - v1
Checksum:i6B26073E169C2FFC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255R → W in BAE29988 (PubMed:16141072).Curated1
Sequence conflicti255R → W in BAE30089 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78682 mRNA. Translation: CAA55349.1.
AK002714 mRNA. Translation: BAB22305.1.
AK010619 mRNA. Translation: BAB27067.1.
AK150956 mRNA. Translation: BAE29988.1.
AK151073 mRNA. Translation: BAE30089.1.
AK168248 mRNA. Translation: BAE40198.1.
AK168656 mRNA. Translation: BAE40512.1.
AL732490 Genomic DNA. Translation: CAI24279.1.
BC083354 mRNA. Translation: AAH83354.1.
BC089034 mRNA. Translation: AAH89034.1.
CCDSiCCDS25280.1.
RefSeqiNP_032857.1. NM_008831.4.
UniGeneiMm.263862.

Genome annotation databases

EnsembliENSMUST00000125172; ENSMUSP00000119603; ENSMUSG00000038845.
GeneIDi18673.
KEGGimmu:18673.
UCSCiuc007lan.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78682 mRNA. Translation: CAA55349.1.
AK002714 mRNA. Translation: BAB22305.1.
AK010619 mRNA. Translation: BAB27067.1.
AK150956 mRNA. Translation: BAE29988.1.
AK151073 mRNA. Translation: BAE30089.1.
AK168248 mRNA. Translation: BAE40198.1.
AK168656 mRNA. Translation: BAE40512.1.
AL732490 Genomic DNA. Translation: CAI24279.1.
BC083354 mRNA. Translation: AAH83354.1.
BC089034 mRNA. Translation: AAH89034.1.
CCDSiCCDS25280.1.
RefSeqiNP_032857.1. NM_008831.4.
UniGeneiMm.263862.

3D structure databases

ProteinModelPortaliP67778.
SMRiP67778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202141. 2 interactors.
IntActiP67778. 12 interactors.
MINTiMINT-1841697.
STRINGi10090.ENSMUSP00000119603.

PTM databases

iPTMnetiP67778.
PhosphoSitePlusiP67778.
SwissPalmiP67778.

2D gel databases

REPRODUCTION-2DPAGEIPI00133440.
P67778.
SWISS-2DPAGEP67778.

Proteomic databases

EPDiP67778.
MaxQBiP67778.
PaxDbiP67778.
PeptideAtlasiP67778.
PRIDEiP67778.
TopDownProteomicsiP67778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000125172; ENSMUSP00000119603; ENSMUSG00000038845.
GeneIDi18673.
KEGGimmu:18673.
UCSCiuc007lan.2. mouse.

Organism-specific databases

CTDi5245.
MGIiMGI:97572. Phb.

Phylogenomic databases

eggNOGiKOG3083. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074770.
HOGENOMiHOG000205692.
HOVERGENiHBG004457.
InParanoidiP67778.
KOiK17080.
OMAiTMANEKQ.
OrthoDBiEOG091G0IHW.
TreeFamiTF300095.

Enzyme and pathway databases

ReactomeiR-MMU-5673000. RAF activation.

Miscellaneous databases

PROiP67778.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038845.
CleanExiMM_PHB.
ExpressionAtlasiP67778. baseline and differential.
GenevisibleiP67778. MM.

Family and domain databases

CDDicd03401. SPFH_prohibitin. 1 hit.
InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHB_MOUSE
AccessioniPrimary (citable) accession number: P67778
Secondary accession number(s): P24142, Q3UB75, Q5SQG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.