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P67778

- PHB_MOUSE

UniProt

P67778 - PHB_MOUSE

Protein

Prohibitin

Gene

Phb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging By similarity.By similarity

    GO - Molecular functioni

    1. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    2. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. cellular response to interleukin-6 Source: Ensembl
    2. DNA biosynthetic process Source: MGI
    3. DNA replication Source: UniProtKB-KW
    4. histone deacetylation Source: Ensembl
    5. negative regulation of androgen receptor signaling pathway Source: Ensembl
    6. negative regulation of cell growth Source: Ensembl
    7. negative regulation of cell proliferation Source: Ensembl
    8. negative regulation of glucocorticoid receptor signaling pathway Source: Ensembl
    9. negative regulation of transcription by competitive promoter binding Source: Ensembl
    10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    11. positive regulation of transcription, DNA-templated Source: Ensembl
    12. progesterone receptor signaling pathway Source: Ensembl
    13. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    DNA synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prohibitin
    Alternative name(s):
    B-cell receptor-associated protein 32
    Short name:
    BAP 32
    Gene namesi
    Name:Phb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:97572. Phb.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrion Source: MGI
    4. nucleoplasm Source: Ensembl
    5. nucleus Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272ProhibitinPRO_0000213879Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281N6-acetyllysine1 Publication
    Modified residuei186 – 1861N6-acetyllysine1 Publication
    Modified residuei202 – 2021N6-acetyllysine; alternate1 Publication
    Modified residuei202 – 2021N6-succinyllysine; alternate1 Publication
    Modified residuei249 – 2491Phosphotyrosine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP67778.
    PaxDbiP67778.
    PRIDEiP67778.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00133440.
    P67778.
    SWISS-2DPAGEP67778.

    PTM databases

    PhosphoSiteiP67778.

    Expressioni

    Tissue specificityi

    Widely expressed in different tissues.1 Publication

    Developmental stagei

    Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas.1 Publication

    Gene expression databases

    BgeeiP67778.
    CleanExiMM_PHB.
    GenevestigatoriP67778.

    Interactioni

    Subunit structurei

    Interacts with PHB2. Interacts with STOML2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi202141. 2 interactions.
    IntActiP67778. 9 interactions.
    MINTiMINT-1841697.

    Structurei

    3D structure databases

    ProteinModelPortaliP67778.
    SMRiP67778. Positions 60-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili177 – 21135Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the prohibitin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0330.
    GeneTreeiENSGT00550000074770.
    HOGENOMiHOG000205692.
    HOVERGENiHBG004457.
    InParanoidiP67778.
    KOiK17080.
    OMAiIIFDVRS.
    OrthoDBiEOG7V4B04.
    TreeFamiTF300095.

    Family and domain databases

    InterProiIPR001107. Band_7.
    IPR000163. Prohibitin.
    [Graphical view]
    PANTHERiPTHR23222. PTHR23222. 1 hit.
    PfamiPF01145. Band_7. 1 hit.
    [Graphical view]
    PRINTSiPR00679. PROHIBITIN.
    SMARTiSM00244. PHB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P67778-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV    50
    GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA 100
    SQLPRIYTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV 150
    SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV 200
    EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ 250
    LSRSRNITYL PAGQSVLLQL PQ 272
    Length:272
    Mass (Da):29,820
    Last modified:October 11, 2004 - v1
    Checksum:i6B26073E169C2FFC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2551R → W in BAE29988. (PubMed:16141072)Curated
    Sequence conflicti255 – 2551R → W in BAE30089. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78682 mRNA. Translation: CAA55349.1.
    AK002714 mRNA. Translation: BAB22305.1.
    AK010619 mRNA. Translation: BAB27067.1.
    AK150956 mRNA. Translation: BAE29988.1.
    AK151073 mRNA. Translation: BAE30089.1.
    AK168248 mRNA. Translation: BAE40198.1.
    AK168656 mRNA. Translation: BAE40512.1.
    AL732490 Genomic DNA. Translation: CAI24279.1.
    BC083354 mRNA. Translation: AAH83354.1.
    BC089034 mRNA. Translation: AAH89034.1.
    CCDSiCCDS25280.1.
    RefSeqiNP_032857.1. NM_008831.4.
    UniGeneiMm.263862.

    Genome annotation databases

    EnsembliENSMUST00000125172; ENSMUSP00000119603; ENSMUSG00000038845.
    GeneIDi18673.
    KEGGimmu:18673.
    UCSCiuc007lan.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78682 mRNA. Translation: CAA55349.1 .
    AK002714 mRNA. Translation: BAB22305.1 .
    AK010619 mRNA. Translation: BAB27067.1 .
    AK150956 mRNA. Translation: BAE29988.1 .
    AK151073 mRNA. Translation: BAE30089.1 .
    AK168248 mRNA. Translation: BAE40198.1 .
    AK168656 mRNA. Translation: BAE40512.1 .
    AL732490 Genomic DNA. Translation: CAI24279.1 .
    BC083354 mRNA. Translation: AAH83354.1 .
    BC089034 mRNA. Translation: AAH89034.1 .
    CCDSi CCDS25280.1.
    RefSeqi NP_032857.1. NM_008831.4.
    UniGenei Mm.263862.

    3D structure databases

    ProteinModelPortali P67778.
    SMRi P67778. Positions 60-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202141. 2 interactions.
    IntActi P67778. 9 interactions.
    MINTi MINT-1841697.

    PTM databases

    PhosphoSitei P67778.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00133440.
    P67778.
    SWISS-2DPAGE P67778.

    Proteomic databases

    MaxQBi P67778.
    PaxDbi P67778.
    PRIDEi P67778.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000125172 ; ENSMUSP00000119603 ; ENSMUSG00000038845 .
    GeneIDi 18673.
    KEGGi mmu:18673.
    UCSCi uc007lan.2. mouse.

    Organism-specific databases

    CTDi 5245.
    MGIi MGI:97572. Phb.

    Phylogenomic databases

    eggNOGi COG0330.
    GeneTreei ENSGT00550000074770.
    HOGENOMi HOG000205692.
    HOVERGENi HBG004457.
    InParanoidi P67778.
    KOi K17080.
    OMAi IIFDVRS.
    OrthoDBi EOG7V4B04.
    TreeFami TF300095.

    Miscellaneous databases

    NextBioi 294690.
    PROi P67778.
    SOURCEi Search...

    Gene expression databases

    Bgeei P67778.
    CleanExi MM_PHB.
    Genevestigatori P67778.

    Family and domain databases

    InterProi IPR001107. Band_7.
    IPR000163. Prohibitin.
    [Graphical view ]
    PANTHERi PTHR23222. PTHR23222. 1 hit.
    Pfami PF01145. Band_7. 1 hit.
    [Graphical view ]
    PRINTSi PR00679. PROHIBITIN.
    SMARTi SM00244. PHB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein."
      Terashima M., Kim K.-M., Adachi T., Nielsen P.J., Reth M., Koehler G., Lamers M.C.
      EMBO J. 13:3782-3792(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Lymphoid tissue.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and DBA/2.
      Tissue: Bone marrow, Heart and Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.
    5. Lubec G., Klug S.
      Submitted (MAR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 12-34; 94-105; 158-177; 220-239 AND 241-253, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hippocampus.
    6. "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence."
      Coates P.J., Nenutil R., McGregor A., Picksley S.M., Crouch D.H., Hall P.A., Wright E.G.
      Exp. Cell Res. 265:262-273(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PHB2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    7. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast and Liver.
    9. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-128; LYS-186 AND LYS-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiPHB_MOUSE
    AccessioniPrimary (citable) accession number: P67778
    Secondary accession number(s): P24142, Q3UB75, Q5SQG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3