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P67778

- PHB_MOUSE

UniProt

P67778 - PHB_MOUSE

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Protein

Prohibitin

Gene
Phb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging By similarity.

GO - Molecular functioni

  1. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  2. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. cellular response to interleukin-6 Source: Ensembl
  2. DNA biosynthetic process Source: MGI
  3. DNA replication Source: UniProtKB-KW
  4. histone deacetylation Source: Ensembl
  5. negative regulation of androgen receptor signaling pathway Source: Ensembl
  6. negative regulation of cell growth Source: Ensembl
  7. negative regulation of cell proliferation Source: Ensembl
  8. negative regulation of glucocorticoid receptor signaling pathway Source: Ensembl
  9. negative regulation of transcription by competitive promoter binding Source: Ensembl
  10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  11. positive regulation of transcription, DNA-templated Source: Ensembl
  12. progesterone receptor signaling pathway Source: Ensembl
  13. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

DNA synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin
Alternative name(s):
B-cell receptor-associated protein 32
Short name:
BAP 32
Gene namesi
Name:Phb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:97572. Phb.

Subcellular locationi

Mitochondrion inner membrane 1 Publication

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrion Source: MGI
  4. nucleoplasm Source: Ensembl
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272ProhibitinPRO_0000213879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281N6-acetyllysine1 Publication
Modified residuei186 – 1861N6-acetyllysine1 Publication
Modified residuei202 – 2021N6-acetyllysine; alternate1 Publication
Modified residuei202 – 2021N6-succinyllysine; alternate1 Publication
Modified residuei249 – 2491Phosphotyrosine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP67778.
PaxDbiP67778.
PRIDEiP67778.

2D gel databases

REPRODUCTION-2DPAGEIPI00133440.
P67778.
SWISS-2DPAGEP67778.

PTM databases

PhosphoSiteiP67778.

Expressioni

Tissue specificityi

Widely expressed in different tissues.1 Publication

Developmental stagei

Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas.1 Publication

Gene expression databases

BgeeiP67778.
CleanExiMM_PHB.
GenevestigatoriP67778.

Interactioni

Subunit structurei

Interacts with PHB2. Interacts with STOML2 By similarity.1 Publication

Protein-protein interaction databases

BioGridi202141. 2 interactions.
IntActiP67778. 9 interactions.
MINTiMINT-1841697.

Structurei

3D structure databases

ProteinModelPortaliP67778.
SMRiP67778. Positions 60-193.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili177 – 21135 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the prohibitin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0330.
GeneTreeiENSGT00550000074770.
HOGENOMiHOG000205692.
HOVERGENiHBG004457.
InParanoidiP67778.
KOiK17080.
OMAiIIFDVRS.
OrthoDBiEOG7V4B04.
TreeFamiTF300095.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P67778-1 [UniParc]FASTAAdd to Basket

« Hide

MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV    50
GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA 100
SQLPRIYTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV 150
SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV 200
EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ 250
LSRSRNITYL PAGQSVLLQL PQ 272
Length:272
Mass (Da):29,820
Last modified:October 11, 2004 - v1
Checksum:i6B26073E169C2FFC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551R → W in BAE29988. 1 Publication
Sequence conflicti255 – 2551R → W in BAE30089. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78682 mRNA. Translation: CAA55349.1.
AK002714 mRNA. Translation: BAB22305.1.
AK010619 mRNA. Translation: BAB27067.1.
AK150956 mRNA. Translation: BAE29988.1.
AK151073 mRNA. Translation: BAE30089.1.
AK168248 mRNA. Translation: BAE40198.1.
AK168656 mRNA. Translation: BAE40512.1.
AL732490 Genomic DNA. Translation: CAI24279.1.
BC083354 mRNA. Translation: AAH83354.1.
BC089034 mRNA. Translation: AAH89034.1.
CCDSiCCDS25280.1.
RefSeqiNP_032857.1. NM_008831.4.
UniGeneiMm.263862.

Genome annotation databases

EnsembliENSMUST00000125172; ENSMUSP00000119603; ENSMUSG00000038845.
GeneIDi18673.
KEGGimmu:18673.
UCSCiuc007lan.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78682 mRNA. Translation: CAA55349.1 .
AK002714 mRNA. Translation: BAB22305.1 .
AK010619 mRNA. Translation: BAB27067.1 .
AK150956 mRNA. Translation: BAE29988.1 .
AK151073 mRNA. Translation: BAE30089.1 .
AK168248 mRNA. Translation: BAE40198.1 .
AK168656 mRNA. Translation: BAE40512.1 .
AL732490 Genomic DNA. Translation: CAI24279.1 .
BC083354 mRNA. Translation: AAH83354.1 .
BC089034 mRNA. Translation: AAH89034.1 .
CCDSi CCDS25280.1.
RefSeqi NP_032857.1. NM_008831.4.
UniGenei Mm.263862.

3D structure databases

ProteinModelPortali P67778.
SMRi P67778. Positions 60-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202141. 2 interactions.
IntActi P67778. 9 interactions.
MINTi MINT-1841697.

PTM databases

PhosphoSitei P67778.

2D gel databases

REPRODUCTION-2DPAGE IPI00133440.
P67778.
SWISS-2DPAGE P67778.

Proteomic databases

MaxQBi P67778.
PaxDbi P67778.
PRIDEi P67778.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000125172 ; ENSMUSP00000119603 ; ENSMUSG00000038845 .
GeneIDi 18673.
KEGGi mmu:18673.
UCSCi uc007lan.2. mouse.

Organism-specific databases

CTDi 5245.
MGIi MGI:97572. Phb.

Phylogenomic databases

eggNOGi COG0330.
GeneTreei ENSGT00550000074770.
HOGENOMi HOG000205692.
HOVERGENi HBG004457.
InParanoidi P67778.
KOi K17080.
OMAi IIFDVRS.
OrthoDBi EOG7V4B04.
TreeFami TF300095.

Miscellaneous databases

NextBioi 294690.
PROi P67778.
SOURCEi Search...

Gene expression databases

Bgeei P67778.
CleanExi MM_PHB.
Genevestigatori P67778.

Family and domain databases

InterProi IPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view ]
PANTHERi PTHR23222. PTHR23222. 1 hit.
Pfami PF01145. Band_7. 1 hit.
[Graphical view ]
PRINTSi PR00679. PROHIBITIN.
SMARTi SM00244. PHB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein."
    Terashima M., Kim K.-M., Adachi T., Nielsen P.J., Reth M., Koehler G., Lamers M.C.
    EMBO J. 13:3782-3792(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Lymphoid tissue.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Bone marrow, Heart and Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  5. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 12-34; 94-105; 158-177; 220-239 AND 241-253, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  6. "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence."
    Coates P.J., Nenutil R., McGregor A., Picksley S.M., Crouch D.H., Hall P.A., Wright E.G.
    Exp. Cell Res. 265:262-273(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PHB2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  7. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast and Liver.
  9. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-128; LYS-186 AND LYS-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPHB_MOUSE
AccessioniPrimary (citable) accession number: P67778
Secondary accession number(s): P24142, Q3UB75, Q5SQG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi