Reviewed, UniProtKB/Swiss-Prot P67765 (CYSE_STAAN)

Names and origin

Protein names

Recommended name:
    Serine acetyltransferase
      Short name=SAT
    EC=2.3.1.30

Gene names

Name:	cysE
Ordered Locus Names:	SA0487

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.
Pathway	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine O-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Serine acetyltransferase		PRO_0000068679

Sequences

	Sequence		Length	Mass (Da)
	P67765-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 78490FFA1013A11F	FASTA	213	23,528
	10 20 30 40 50 60 MLKRMRDDIK MVFEQDPAAR STLEVITTYA GLHAVWSHLI AHKLYNQKKY VAARAISQIS 70 80 90 100 110 120 RFFTGIEIHP GAKIGKRLFI DHGMGVVIGE TCTIGDNVTI YQGVTLGGTG KERGKRHPDI 130 140 150 160 170 180 GDNVLIAAGA KVLGNIKINS NVNIGANSVV LQSVPSYSTV VGIPGHIVKQ DGVRVGKTFD 190 200 210 HRHLPDPIYE QIKHLERQLE KTRNGEIQDD YII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315." Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F. Submitted (OCT-2007) to UniProtKB Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000018 Genomic DNA. Translation: BAB41717.1.
PIR	B89820.
RefSeq	NP_373739.1.
3D structure databases
SMR	P67765. Positions 3-168, 119-201.
ModBase	Search...
Protein-protein interaction databases
STRING	P67765.
Genome annotation databases
GeneID	1123291.
GenomeReviews	Gene locus SA0487 in contig BA000018_GR.
KEGG	sau:SA0487.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1045.
HOGENOM	HBG754554.
OMA	SHGKRHP.
Enzyme and pathway databases
BioCyc	SAUR158879:SA0487-MONOMER.
Family and domain databases
InterPro	IPR005881. Ser_O-AcTrfase. IPR011004. Trimer_LpxA-like. [Graphical view]
TIGRFAMs	TIGR01172. cysE. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSE_STAAN

Accession

Primary (citable) accession number: P67765
Secondary accession number(s): Q99W74

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)