P67764 (CYSE_STAAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine acetyltransferase
Short name=SAT
EC=2.3.1.30

Gene names

Name:	cysE
Ordered Locus Names:	SAV0529

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.
Pathway	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine O-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Serine acetyltransferase		PRO_0000068678

Sequences

	Sequence		Length	Mass (Da)
	P67764 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 78490FFA1013A11F	FASTA	213	23,528
	10 20 30 40 50 60 MLKRMRDDIK MVFEQDPAAR STLEVITTYA GLHAVWSHLI AHKLYNQKKY VAARAISQIS 70 80 90 100 110 120 RFFTGIEIHP GAKIGKRLFI DHGMGVVIGE TCTIGDNVTI YQGVTLGGTG KERGKRHPDI 130 140 150 160 170 180 GDNVLIAAGA KVLGNIKINS NVNIGANSVV LQSVPSYSTV VGIPGHIVKQ DGVRVGKTFD 190 200 210 HRHLPDPIYE QIKHLERQLE KTRNGEIQDD YII

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000017 Genomic DNA. Translation: BAB56691.1.
RefSeq	NP_371053.1. NC_002758.2.
3D structure databases
ProteinModelPortal	P67764.
ModBase	Search...
Protein-protein interaction databases
STRING	P67764.
2D gel databases
World-2DPAGE	0002:P67764.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000007702; EBSTAP00000007520; EBSTAG00000007701.
GeneID	1120502.
GenomeReviews	Gene locus SAV0529 in contig BA000017_GR.
KEGG	sav:SAV0529.
PATRIC	19561708. VBIStaAur52173_0534.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1045.
GeneTree	EBGT00050000024445.
HOGENOM	HBG754554.
OMA	GGTGKSH.
ProtClustDB	CLSK884712.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV0529-MONOMER.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR005881. Ser_O-AcTrfase. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00640.
Pfam	PF00132. Hexapep. 2 hits. [Graphical view]
PIRSF	PIRSF000441. CysE. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01172. CysE. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSE_STAAM

Accession

Primary (citable) accession number: P67764
Secondary accession number(s): Q99W74

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program