Reviewed,
UniProtKB/Swiss-Prot P67733 (COABC_MYCTU)
Last modified
June 16, 2009.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Coenzyme A biosynthesis bifunctional protein coaBC Alternative name(s): DNA/pantothenate metabolism flavoprotein Including the following 2 domains: 1- Recommended name: Phosphopantothenoylcysteine decarboxylase Short name=PPCDC EC=4.1.1.36 Alternative name(s): CoaC 2- Recommended name: Phosphopantothenate--cysteine ligase EC=6.3.2.5 Alternative name(s): Phosphopantothenoylcysteine synthase PPC synthetase Short name=PPCS CoaB | ||||||||
| Gene names |
| ||||||||
| Organism | Mycobacterium tuberculosis [Complete proteome] [HAMAP] | ||||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 418 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine By similarity. |
| Catalytic activity | N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2. CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + PPi + N-((R)-4'-phosphopantothenoyl)-L-cysteine. |
| Cofactor | Binds 1 FMN per subunit By similarity. |
| Pathway | Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 2/5. Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 3/5. |
| Subunit structure | Homododecamer, the coaB domains form homodimers. |
| Sequence similarities | In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily. In the C-terminal section; belongs to the PPC synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FMN Flavoprotein |
| Molecular function | Decarboxylase Ligase Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | coenzyme A biosynthetic process Inferred from electronic annotation. Source: InterPro pantothenate catabolic processInferred from electronic annotation. Source: InterPro |
| Molecular function | FMN binding Inferred from electronic annotation. Source: InterPro phosphopantothenate--cysteine ligase activityInferred from electronic annotation. Source: EC phosphopantothenoylcysteine decarboxylase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 418 | 418 | Coenzyme A biosynthesis bifunctional protein coaBC | PRO_0000232694 | |||||
Regions | |||||||||
| Region | 1 – 193 | 193 | Phosphopantothenoylcysteine decarboxylase | ||||||
| Region | 194 – 418 | 225 | Phosphopantothenate--cysteine ligase | ||||||
Sites | |||||||||
| Binding site | 285 | 1 | CTP By similarity | ||||||
| Binding site | 295 | 1 | CTP By similarity | ||||||
| Binding site | 354 | 1 | CTP By similarity | ||||||
| Binding site | 358 | 1 | CTP By similarity | ||||||
Sequences
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References
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
Cross-references
Sequence databases | |
|---|---|
| BX842576 Genomic DNA. Translation: CAB02174.1. AE000516 Genomic DNA. Translation: AAK45701.1. | |
| PIR | E70899. |
| RefSeq | NP_215907.1. NP_335887.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MVN based on UniProtKB Q9SWE5. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 886749. 924547. |
| GenomeReviews | Gene locus MT1436 in contig AE000516_GR. Gene locus Rv1391 in contig AL123456_GR. |
| KEGG | mtc:MT1436. mtu:Rv1391. |
| TIGR | MT1436. |
Organism-specific databases | |
| TubercuList | Rv1391. |
Phylogenomic databases | |
| HOGENOM | P67733. |
| OMA | P67733. VTSGPTH. |
Enzyme and pathway databases | |
| BRENDA | 4.1.1.36. 809. 6.3.2.5. 809. |
Family and domain databases | |
| InterPro | IPR005252. Bifunc_COABC. IPR007085. DNA/pantothenate-metab_flavo_C. IPR003382. Flavoprotein. [Graphical view] |
| Gene3D | G3DSA:3.40.50.10300. DNA/pantothenate-metab_flavo_C. 1 hit. G3DSA:3.40.50.1950. Flavoprotein. 1 hit. |
| Pfam | PF04127. DFP. 1 hit. PF02441. Flavoprotein. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00521. coaBC_dfp. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | COABC_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P67733 Secondary accession number(s): P71661 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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