P67733 (COABC_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Coenzyme A biosynthesis bifunctional protein CoaBC Alternative name(s): DNA/pantothenate metabolism flavoprotein | ||||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis | ||||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 418 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine By similarity. |
| Catalytic activity | N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2. CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + PPi + N-((R)-4'-phosphopantothenoyl)-L-cysteine. |
| Cofactor | Binds 1 FMN per subunit By similarity. |
| Pathway | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5. Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. |
| Subunit structure | Homododecamer, the CoaB domains form homodimers. |
| Miscellaneous | Was identified as a high-confidence drug target. |
| Sequence similarities | In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily. In the C-terminal section; belongs to the PPC synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FMN Flavoprotein |
| Molecular function | Decarboxylase Ligase Lyase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | coenzyme A biosynthetic process Inferred from direct assay. Source: MTBBASE growthInferred from mutant phenotype. Source: MTBBASE pantothenate catabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | plasma membrane Inferred from direct assay. Source: MTBBASE |
| Molecular function | FMN binding Inferred from electronic annotation. Source: InterPro phosphopantothenate--cysteine ligase activityInferred from electronic annotation. Source: EC phosphopantothenoylcysteine decarboxylase activityInferred from direct assay. Source: MTBBASE |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 418 | 418 | Coenzyme A biosynthesis bifunctional protein CoaBC | PRO_0000232694 | |||||
Regions | |||||||||
| Region | 1 – 193 | 193 | Phosphopantothenoylcysteine decarboxylase | ||||||
| Region | 194 – 418 | 225 | Phosphopantothenate--cysteine ligase | ||||||
Sites | |||||||||
| Binding site | 285 | 1 | CTP By similarity | ||||||
| Binding site | 295 | 1 | CTP By similarity | ||||||
| Binding site | 354 | 1 | CTP By similarity | ||||||
| Binding site | 358 | 1 | CTP By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842576 Genomic DNA. Translation: CAB02174.1. AE000516 Genomic DNA. Translation: AAK45701.1. |
| PIR | E70899. |
| RefSeq | NP_215907.1. NC_000962.2. NP_335887.1. NC_002755.2. |
3D structure databases | |
| ProteinModelPortal | P67733. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000001175; EBMYCP00000001175; EBMYCG00000001175. EBMYCT00000071608; EBMYCP00000069667; EBMYCG00000071603. |
| GeneID | 886749. 924547. |
| GenomeReviews | Gene locus MT1436 in contig AE000516_GR. Gene locus Rv1391 in contig AL123456_GR. |
| KEGG | mtc:MT1436. mtu:Rv1391. |
| PATRIC | 18124926. VBIMycTub22151_1577. |
| TIGR | MT1436. |
Organism-specific databases | |
| TubercuList | Rv1391. |
Phylogenomic databases | |
| GeneTree | EBGT00050000017596. |
| HOGENOM | HBG523890. |
| OMA | VTSGPTH. |
| PhylomeDB | P67733. |
| ProtClustDB | PRK05579. |
Family and domain databases | |
| InterPro | IPR005252. Bifunc_COABC. IPR007085. DNA/pantothenate-metab_flavo_C. IPR003382. Flavoprotein. [Graphical view] |
| Gene3D | G3DSA:3.40.50.10300. DNA/pantothenate-metab_flavo_C. 1 hit. G3DSA:3.40.50.1950. Flavoprotein. 1 hit. |
| KO | K13038. |
| Pfam | PF04127. DFP. 1 hit. PF02441. Flavoprotein. 1 hit. [Graphical view] |
| SUPFAM | SSF102645. DNA/pantothenate-metab_flavo_C. 1 hit. SSF52507. Flavoprotein. 1 hit. |
| TIGRFAMs | TIGR00521. CoaBC_dfp. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | COABC_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P67733 Secondary accession number(s): P71661 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with