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Protein

HTH-type transcriptional regulator CmtR

Gene

cmtR

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57CadmiumPROSITE-ProRule annotation1
Metal bindingi61CadmiumPROSITE-ProRule annotation1
Metal bindingi102Cadmium; shared with dimeric partnerPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandCadmium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CmtR
Gene namesi
Name:cmtR
Ordered Locus Names:BQ2027_MB2017C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606301 – 118HTH-type transcriptional regulator CmtRAdd BLAST118

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP67732.
SMRiP67732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 97HTH arsR-typePROSITE-ProRule annotationAdd BLAST95

Phylogenomic databases

HOGENOMiHOG000144506.
KOiK21885.
OMAiADEKGCC.

Family and domain databases

CDDicd00090. HTH_ARSR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011991. ArsR-like_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF01022. HTH_5. 1 hit.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P67732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTCEMRESA LARLGRALAD PTRCRILVAL LDGVCYPGQL AAHLGLTRSN
60 70 80 90 100
VSNHLSCLRG CGLVVATYEG RQVRYALADS HLARALGELV QVVLAVDTDQ
110
PCVAERAASG EAVEMTGS
Length:118
Mass (Da):12,495
Last modified:October 11, 2004 - v1
Checksum:i1997F68DC2574989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIU00624.1.
RefSeqiNP_855667.1. NC_002945.3.
WP_003410018.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO43269; CDO43269; Mb2017c.
KEGGimbo:Mb2017c.
PATRICifig|233413.5.peg.2216.

Similar proteinsi

Entry informationi

Entry nameiCMTR_MYCBO
AccessioniPrimary (citable) accession number: P67732
Secondary accession number(s): A0A1R3Y214, Q10864, X2BJI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 31, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome