P67729 (YFEO_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ion-transport protein YfeO

Gene names

Name:	yfeO
Ordered Locus Names:	b2389, JW2386

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_01115.
Sequence similarities	Belongs to the chloride channel (TC 2.A.49) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	voltage-gated chloride channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Putative ion-transport protein YfeO HAMAP-Rule MF_01115		PRO_0000094494
Regions
	Transmembrane	9 – 31	23	Helical; Potential
	Transmembrane	55 – 77	23	Helical; Potential
	Transmembrane	90 – 112	23	Helical; Potential
	Transmembrane	122 – 140	19	Helical; Potential
	Transmembrane	147 – 169	23	Helical; Potential
	Transmembrane	189 – 211	23	Helical; Potential
	Transmembrane	223 – 244	22	Helical; Potential
	Transmembrane	259 – 281	23	Helical; Potential
	Transmembrane	301 – 323	23	Helical; Potential
	Transmembrane	343 – 363	21	Helical; Potential
	Transmembrane	376 – 398	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P67729 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: B6916E8F62F3156C	FASTA	418	43,574
	10 20 30 40 50 60 MLHPRARTML LLSLPAVAIG IASSLILIVV MKIASVLQNL LWQRLPGTLG IAQDSPLWII 70 80 90 100 110 120 GVLTLTGIAV GLVIRFSQGH AGPDPACEPL IGAPVPPSAL PGLIVALILG LAGGVSLGPE 130 140 150 160 170 180 HPIMTVNIAL AVAIGARLLP RVNRMEWTIL ASAGTIGALF GTPVAAALIF SQTLNGSSEV 190 200 210 220 230 240 PLWDRLFAPL MAAAAGALTT GLFFHPHFSL PIAHYGQMEM TDILSGAIVA AIAIAAGMVA 250 260 270 280 290 300 VWCLPRLHAM MHQMKNPVLV LGIGGFILGI LGVIGGPVSL FKGLDEMQQM VANQAFSTSD 310 320 330 340 350 360 YFLLAVIKLA ALVVAAASGF RGGRIFPAVF VGVALGLMLH EHVPAVPAAI TVSCAILGIV 370 380 390 400 410 LVVTRDGWLS LFMAAVVVPN TTLLPLLCIV MLPAWLLLAG KPMMMVNRPK QQPPHDNV

References

[1]

"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.

[2]

"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC75448.1. AP009048 Genomic DNA. Translation: BAE76708.1.
PIR	B65013.
RefSeq	NP_416890.1. NC_000913.2. YP_490631.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P67729.
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b2389.
Proteomic databases
PRIDE	P67729.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75448; AAC75448; b2389. BAE76708; BAE76708; BAE76708.
GeneID	12930187. 946854.
KEGG	ecj:Y75_p2356. eco:b2389.
PATRIC	32120157. VBIEscCol129921_2487.
Organism-specific databases
EchoBASE	EB3908.
EcoGene	EG14156. yfeO.
Phylogenomic databases
eggNOG	COG0038.
HOGENOM	HOG000267985.
OMA	CGFRGGR.
ProtClustDB	PRK03655.
Enzyme and pathway databases
BioCyc	EcoCyc:G7251-MONOMER. ECOL316407:JW2386-MONOMER.
Gene expression databases
Genevestigator	P67729.
Family and domain databases
Gene3D	1.10.3080.10. 1 hit.
HAMAP	MF_01115. CLC_YfeO.
InterPro	IPR022969. Chloride_channel_YfeO. IPR014743. Cl-channel_core. IPR001807. Cl-channel_volt-gated. [Graphical view]
Pfam	PF00654. Voltage_CLC. 1 hit. [Graphical view]
PRINTS	PR00762. CLCHANNEL.
SUPFAM	SSF81340. Cl-channel_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YFEO_ECOLI

Accession

Primary (citable) accession number: P67729
Secondary accession number(s): P76526, Q2MAJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program