Reviewed, UniProtKB/Swiss-Prot P67662 (AAER_ECOLI)

Names and origin

Protein names

Recommended name:
    HTH-type transcriptional activator aaeR

Gene names

Name:	aaeR
Synonyms:	yhcS
Ordered Locus Names:	b3243, JW3212

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	Activates transcription of the aaeXAB operon. Ref.3
Sequence similarities	Contains 1 HTH lysR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	HTH-type transcriptional activator aaeR		PRO_0000105580
Regions
	Domain	1 – 59	59	HTH lysR-type
	DNA binding	19 – 38	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	P67662-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 22DF64653AF4BE2F	FASTA	309	34,516
	10 20 30 40 50 60 MERLKRMSVF AKVVEFGSFT AAARQLQMSV SSISQTVSKL EDELQVKLLN RSTRSIGLTE 70 80 90 100 110 120 AGRIYYQGCR RMLHEVQDVH EQLYAFNNTP IGTLRIGCSS TMAQNVLAGL TAKMLKEYPG 130 140 150 160 170 180 LSVNLVTGIP APDLIADGLD VVIRVGALQD SSLFSRRLGA MPMVVCAAKS YLTQYGIPEK 190 200 210 220 230 240 PADLSSHSWL EYSVRPDNEF ELIAPEGIST RLIPQGRFVT NDPMTLVRWL TAGAGIAYVP 250 260 270 280 290 300 LMWVINEINR GELEILLPRY QSDPRPVYAL YTEKDKLPLK VQVVINSLTD YFVEVGKLFQ EMHGRGKEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?" Van Dyk T.K., Templeton L.J., Cantera K.A., Sharpe P.L., Sariaslani F.S. J. Bacteriol. 186:7196-7204(2004) [PubMed: 15489430] [Abstract] Cited for: FUNCTION. Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18997 Genomic DNA. Translation: AAA58045.1. U00096 Genomic DNA. Translation: AAC76275.1. AP009048 Genomic DNA. Translation: BAE77286.1.
PIR	E65116.
RefSeq	AP_003785.1. NP_417710.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	947760.
GenomeReviews	Gene locus JW3212 in contig AP009048_GR. Gene locus b3243 in contig U00096_GR.
KEGG	ecj:JW3212. eco:b3243.
Organism-specific databases
EchoBASE	EB2676.
EcoGene	EG12825. aaeR.
CMR	Search...
Phylogenomic databases
HOGENOM	P67662.
OMA	P67662. KVQVCIN.
Enzyme and pathway databases
BioCyc	EcoCyc:G7688-MON.
Family and domain databases
InterPro	IPR000847. HTH_LysR. IPR005119. LysR_subst_bd. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00126. HTH_1. 1 hit. PF03466. LysR_substrate. 1 hit. [Graphical view]
PROSITE	PS50931. HTH_LYSR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAER_ECOLI

Accession

Primary (citable) accession number: P67662
Secondary accession number(s): P45691, Q2M8X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)