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Protein

HTH-type transcriptional activator AaeR

Gene

aaeR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Activates transcription of the aaeXAB operon.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi19 – 38H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • DNA-templated transcription, initiation Source: EcoliWiki
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • regulation of transcription, DNA-templated Source: EcoliWiki
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7688-MONOMER.
ECOL316407:JW3212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator AaeR
Gene namesi
Name:aaeR
Synonyms:yhcS
Ordered Locus Names:b3243, JW3212
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12825. aaeR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001055801 – 309HTH-type transcriptional activator AaeRAdd BLAST309

Proteomic databases

PaxDbiP67662.
PRIDEiP67662.

Interactioni

Protein-protein interaction databases

BioGridi4260796. 7 interactors.
DIPiDIP-12291N.
IntActiP67662. 3 interactors.
STRINGi511145.b3243.

Structurei

3D structure databases

ProteinModelPortaliP67662.
SMRiP67662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 59HTH lysR-typePROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CR8. Bacteria.
ENOG410XNYU. LUCA.
HOGENOMiHOG000233519.
InParanoidiP67662.
OMAiKSYLAQY.
PhylomeDBiP67662.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P67662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLKRMSVF AKVVEFGSFT AAARQLQMSV SSISQTVSKL EDELQVKLLN
60 70 80 90 100
RSTRSIGLTE AGRIYYQGCR RMLHEVQDVH EQLYAFNNTP IGTLRIGCSS
110 120 130 140 150
TMAQNVLAGL TAKMLKEYPG LSVNLVTGIP APDLIADGLD VVIRVGALQD
160 170 180 190 200
SSLFSRRLGA MPMVVCAAKS YLTQYGIPEK PADLSSHSWL EYSVRPDNEF
210 220 230 240 250
ELIAPEGIST RLIPQGRFVT NDPMTLVRWL TAGAGIAYVP LMWVINEINR
260 270 280 290 300
GELEILLPRY QSDPRPVYAL YTEKDKLPLK VQVVINSLTD YFVEVGKLFQ

EMHGRGKEK
Length:309
Mass (Da):34,516
Last modified:October 11, 2004 - v1
Checksum:i22DF64653AF4BE2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58045.1.
U00096 Genomic DNA. Translation: AAC76275.1.
AP009048 Genomic DNA. Translation: BAE77286.1.
PIRiE65116.
RefSeqiNP_417710.1. NC_000913.3.
WP_000440317.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76275; AAC76275; b3243.
BAE77286; BAE77286; BAE77286.
GeneIDi947760.
KEGGiecj:JW3212.
eco:b3243.
PATRICi32121912. VBIEscCol129921_3340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58045.1.
U00096 Genomic DNA. Translation: AAC76275.1.
AP009048 Genomic DNA. Translation: BAE77286.1.
PIRiE65116.
RefSeqiNP_417710.1. NC_000913.3.
WP_000440317.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP67662.
SMRiP67662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260796. 7 interactors.
DIPiDIP-12291N.
IntActiP67662. 3 interactors.
STRINGi511145.b3243.

Proteomic databases

PaxDbiP67662.
PRIDEiP67662.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76275; AAC76275; b3243.
BAE77286; BAE77286; BAE77286.
GeneIDi947760.
KEGGiecj:JW3212.
eco:b3243.
PATRICi32121912. VBIEscCol129921_3340.

Organism-specific databases

EchoBASEiEB2676.
EcoGeneiEG12825. aaeR.

Phylogenomic databases

eggNOGiENOG4105CR8. Bacteria.
ENOG410XNYU. LUCA.
HOGENOMiHOG000233519.
InParanoidiP67662.
OMAiKSYLAQY.
PhylomeDBiP67662.

Enzyme and pathway databases

BioCyciEcoCyc:G7688-MONOMER.
ECOL316407:JW3212-MONOMER.

Miscellaneous databases

PROiP67662.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAER_ECOLI
AccessioniPrimary (citable) accession number: P67662
Secondary accession number(s): P45691, Q2M8X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.