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Protein

HTH-type transcriptional activator AaeR

Gene

aaeR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Activates transcription of the aaeXAB operon.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi19 – 38H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • DNA-templated transcription, initiation Source: EcoliWiki
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • regulation of transcription, DNA-templated Source: EcoliWiki
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7688-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator AaeR
Gene namesi
Name:aaeR
Synonyms:yhcS
Ordered Locus Names:b3243, JW3212
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12825 aaeR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001055801 – 309HTH-type transcriptional activator AaeRAdd BLAST309

Proteomic databases

PaxDbiP67662
PRIDEiP67662

Interactioni

Protein-protein interaction databases

BioGridi4260796, 7 interactors
DIPiDIP-12291N
IntActiP67662, 3 interactors
STRINGi316385.ECDH10B_3420

Structurei

3D structure databases

ProteinModelPortaliP67662
SMRiP67662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 59HTH lysR-typePROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiENOG4105CR8 Bacteria
ENOG410XNYU LUCA
HOGENOMiHOG000233519
InParanoidiP67662
KOiK21698
OMAiKPADMVN
PhylomeDBiP67662

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P67662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLKRMSVF AKVVEFGSFT AAARQLQMSV SSISQTVSKL EDELQVKLLN
60 70 80 90 100
RSTRSIGLTE AGRIYYQGCR RMLHEVQDVH EQLYAFNNTP IGTLRIGCSS
110 120 130 140 150
TMAQNVLAGL TAKMLKEYPG LSVNLVTGIP APDLIADGLD VVIRVGALQD
160 170 180 190 200
SSLFSRRLGA MPMVVCAAKS YLTQYGIPEK PADLSSHSWL EYSVRPDNEF
210 220 230 240 250
ELIAPEGIST RLIPQGRFVT NDPMTLVRWL TAGAGIAYVP LMWVINEINR
260 270 280 290 300
GELEILLPRY QSDPRPVYAL YTEKDKLPLK VQVVINSLTD YFVEVGKLFQ

EMHGRGKEK
Length:309
Mass (Da):34,516
Last modified:October 11, 2004 - v1
Checksum:i22DF64653AF4BE2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58045.1
U00096 Genomic DNA Translation: AAC76275.1
AP009048 Genomic DNA Translation: BAE77286.1
PIRiE65116
RefSeqiNP_417710.1, NC_000913.3
WP_000440317.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76275; AAC76275; b3243
BAE77286; BAE77286; BAE77286
GeneIDi947760
KEGGiecj:JW3212
eco:b3243
PATRICifig|1411691.4.peg.3485

Similar proteinsi

Entry informationi

Entry nameiAAER_ECOLI
AccessioniPrimary (citable) accession number: P67662
Secondary accession number(s): P45691, Q2M8X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health