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P67657 (MTNN_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
MTA/SAH nucleosidase
EC=3.2.2.9
Alternative name(s):
5'-methylthioadenosine nucleosidase
S-adenosylhomocysteine nucleosidase
Gene names
Name:mtnN
Synonyms:mtn
Ordered Locus Names:Mb0094
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) By similarity.

Catalytic activity

S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine.

S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine.

Methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose.

Sequence similarities

Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255MTA/SAH nucleosidase
PRO_0000164445

Sequences

Sequence LengthMass (Da)Tools
P67657 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: EA80AA80B2BFEE79

FASTA25527,340
        10         20         30         40         50         60 
MAVTVGVICA IPQELAYLRG VLVDAKRQQV AQILFDSGQL DAHRVVLAAA GMGKVNTGLT 

        70         80         90        100        110        120 
ATLLADRFGC RTIVFTGVAG GLDPELCIGD IVIADRVVQH DFGLLTDERL RPYQPGHIPF 

       130        140        150        160        170        180 
IEPTERLGYP VDPAVIDRVK HRLDGFTLAP LSTAAGGGGR QPRIYYGTIL TGDQYLHCER 

       190        200        210        220        230        240 
TRNRLHHELG GMAVEMEGGA VAQICASFDI PWLVIRALSD LAGADSGVDF NRFVGEVAAS 

       250 
SARVLLRLLP VLTAC

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248334 Genomic DNA. Translation: CAD92956.1.
RefSeqNP_853762.1. NC_002945.3.

3D structure databases

ProteinModelPortalP67657.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000017998; EBMYCP00000017833; EBMYCG00000017993.
GeneID1090778.
GenomeReviewsGene locus Mb0094 in contig BX248333_GR.
KEGGmbo:Mb0094.
PATRIC18001876. VBIMycBov88188_0106.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000018357.
HOGENOMHBG367723.
OMANVFWINT.
ProtClustDBCLSK790256.

Enzyme and pathway databases

BioCycMBOV233413:MB0094-MONOMER.

Family and domain databases

InterProIPR010049. MTA_SAH_Nsdase.
IPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
KOK01243.
PANTHERPTHR21234. PNP_UDP. 1 hit.
PTHR21234:SF6. PTHR21234:SF6. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTNN_MYCBO
AccessionPrimary (citable) accession number: P67657
Secondary accession number(s): Q10889
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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