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Reviewed, UniProtKB/Swiss-Prot P67654 (KDSC_SHIFL)

Last modified June 16, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
    EC=3.1.3.45
Alternative name(s):
    KDO 8-P phosphatase
Gene names
Name: kdsC
Ordered Locus Names: SF3238, S3456
OrganismShigella flexneri [Complete proteome] [HAMAP]
Taxonomic identifier623 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate By similarity.

Catalytic activity

3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate.

Cofactor

Magnesium Probable.

Pathway

Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3.

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the kdsC family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   LigandMagnesium
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-deoxy-manno-octulosonate-8-phosphatase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1881883-deoxy-D-manno-octulosonate 8-phosphate phosphatase
PRO_0000201701

Sequences

Sequence LengthMass (Da)Tools
P67654-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 6A40ED8C20B1E3A7

FASTA18820,015
        10         20         30         40         50         60 
MSKAGASLAT CYGPVSADVM AKAENIRLLI LDVDGVLSDG LIYMGNNGEE LKAFNVRDGY 

        70         80         90        100        110        120 
GIRCALTSDI EVAIITGRKA KLVEDRCATL GITHLYQGQS NKLIAFSDLL EKLAIAPENV 

       130        140        150        160        170        180 
AYVGDDLIDW PVMEKVGLSV AVADAHPLLI PRADYVTRIA GGRGAVREVC DLLLLAQGKL 


DEAKGQSI 

« Hide

References

[1]"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. expand/collapse author list , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 301 / Serotype 2a.
[2]"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T."
Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.
Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases

AE005674 Genomic DNA. Translation: AAN44704.1.
AE014073 Genomic DNA. Translation: AAP18518.1.
RefSeqNP_708997.1.
NP_838707.1.

3D structure databases

HSSPHSSP built from PDB template 1K1E based on UniProtKB P45314.
ModBaseSearch...

Genome annotation databases

GeneID1027121.
1079690.
GenomeReviewsGene locus SF3238 in contig AE005674_GR.
Gene locus S3456 in contig AE014073_GR.
KEGGsfl:SF3238.
sfx:S3456.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP67654.
OMAP67654. KTFNTLD.

Enzyme and pathway databases

BioCycSFLE198214:AAN44704.1-MON.
BRENDA3.1.3.45. 189495.

Family and domain databases

InterProIPR013200. HAD-SF_hydro-like_3.
IPR006549. HAD-SF_hydro_IIIA.
IPR010023. Phosphatase_KdsC.
[Graphical view]
PfamPF08282. Hydrolase_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR01662. HAD-SF-IIIA. 1 hit.
TIGR01670. YrbI-phosphatas. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSC_SHIFL
AccessionPrimary (citable) accession number: P67654
Secondary accession number(s): Q83JF3, Q8FD72
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents