P67654 (KDSC_SHIFL) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC EC=3.1.3.45 Alternative name(s): KDO 8-P phosphatase | ||||
| Gene names |
| ||||
| Organism | Shigella flexneri [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 623 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate By similarity. |
| Catalytic activity | 3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. |
| Cofactor | Magnesium Probable. |
| Pathway | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the kdsC family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipopolysaccharide biosynthesis |
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-deoxy-manno-octulosonate-8-phosphatase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 188 | 188 | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC | PRO_0000201701 | |||||
Regions | |||||||||
| Region | 32 – 34 | 3 | Substrate binding By similarity | ||||||
| Region | 55 – 59 | 5 | Substrate binding By similarity | ||||||
| Region | 76 – 77 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Metal binding | 32 | 1 | Magnesium By similarity | ||||||
| Metal binding | 34 | 1 | Magnesium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 125 | 1 | Magnesium By similarity | ||||||
| Binding site | 34 | 1 | Substrate By similarity | ||||||
| Binding site | 63 | 1 | Substrate By similarity | ||||||
| Binding site | 78 | 1 | Substrate By similarity | ||||||
| Binding site | 86 | 1 | Substrate By similarity | ||||||
| Binding site | 102 | 1 | Substrate By similarity | ||||||
| Binding site | 187 | 1 | Substrate; via carbonyl oxygen By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. Yu J.Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a. |
| [2] | "Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE005674 Genomic DNA. Translation: AAN44704.1. AE014073 Genomic DNA. Translation: AAP18518.1. |
| RefSeq | NP_708997.1. NC_004337.2. NP_838707.1. NC_004741.1. |
3D structure databases | |
| ProteinModelPortal | P67654. |
| SMR | P67654. Positions 8-188. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000085134; EBESCP00000081956; EBESCG00000084180. EBESCT00000089706; EBESCP00000086342; EBESCG00000088750. |
| GeneID | 1027121. 1079690. |
| GenomeReviews | Gene locus SF3238 in contig AE005674_GR. Gene locus S3456 in contig AE014073_GR. |
| KEGG | sfl:SF3238. sfx:S3456. |
| PATRIC | 18708663. VBIShiFle31049_3777. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000009685. |
| HOGENOM | HBG471796. |
| OMA | KTFNTLD. |
| ProtClustDB | PRK09484. |
Enzyme and pathway databases | |
| BioCyc | SFLE198214:AAN44704.1-MONOMER. |
Family and domain databases | |
| InterPro | IPR023214. HAD-like_dom. IPR013200. HAD-SF_hydro-like_3. IPR010023. KDO_8-P_phosphatase. [Graphical view] |
| Gene3D | G3DSA:3.40.50.1000. HAD-like_dom. 1 hit. |
| KO | K03270. |
| PANTHER | PTHR26053. PTHR26053. 1 hit. |
| Pfam | PF08282. Hydrolase_3. 1 hit. [Graphical view] |
| PIRSF | PIRSF006118. KDO8-P_Ptase. 1 hit. |
| SUPFAM | SSF56784. HAD-like_dom. 1 hit. |
| TIGRFAMs | TIGR01670. YrbI-phosphatas. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | KDSC_SHIFL | ||||||||
| Accession | Primary (citable) accession number: P67654 Secondary accession number(s): Q83JF3, Q8FD72 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with