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Protein

Lysine--tRNA ligase 1

Gene

lysS1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

There are two lysyl-tRNA ligases in M.bovis.

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi415Magnesium 1By similarity1
Metal bindingi422Magnesium 1By similarity1
Metal bindingi422Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-3806-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase 1 (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase 1
Short name:
LysRS 1
Gene namesi
Name:lysS1
Synonyms:lysS
Ordered Locus Names:BQ2027_MB3629C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526541 – 505Lysine--tRNA ligase 1Add BLAST505

Proteomic databases

PRIDEiP67608

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP67608
SMRiP67608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000236578
OMAiMMNIIPG

Family and domain databases

HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P67608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAADTAEDL PEQFRIRRDK RARLLAQGRD PYPVAVPRTH TLAEVRAAHP
60 70 80 90 100
DLPIDTATED IVGVAGRVIF ARNSGKLCFA TLQDGDGTQL QVMISLDKVG
110 120 130 140 150
QAALDAWKAD VDLGDIVYVH GAVISSRRGE LSVLADCWRI AAKSLRPLPV
160 170 180 190 200
AHKEMSEESR VRQRYVDLIV RPEARAVARL RIAVVRAIRT ALQRRGFLEV
210 220 230 240 250
ETPVLQTLAG GAAARPFATH SNALDIDLYL RIAPELFLKR CIVGGFDKVF
260 270 280 290 300
ELNRVFRNEG ADSTHSPEFS MLETYQTYGT YDDSAVVTRE LIQEVADEAI
310 320 330 340 350
GTRQLPLPDG SVYDIDGEWA TIQMYPSLSV ALGEEITPQT TVDRLRGIAD
360 370 380 390 400
SLGLEKDPAI HDNRGFGHGK LIEELWERTV GKSLSAPTFV KDFPVQTTPL
410 420 430 440 450
TRQHRSIPGV TEKWDLYLRG IELATGYSEL SDPVVQRERF ADQARAAAAG
460 470 480 490 500
DDEAMVLDED FLAALEYGMP PCTGTGMGID RLLMSLTGLS IRETVLFPIV

RPHSN
Length:505
Mass (Da):55,709
Last modified:October 11, 2004 - v1
Checksum:iE12FFC867152740C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU02256.1
RefSeqiNP_857268.1, NC_002945.3
WP_003419514.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO44899; CDO44899; Mb3629c
PATRICifig|233413.5.peg.3975

Similar proteinsi

Entry informationi

Entry nameiSYK1_MYCBO
AccessioniPrimary (citable) accession number: P67608
Secondary accession number(s): A0A1R3Y573, O06284, X2BNU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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