Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133L-tryptophanUniRule annotation1
Binding sitei184ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi145 – 147ATPUniRule annotation3
Nucleotide bindingi193 – 197ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MW0878
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366801 – 329Tryptophan--tRNA ligaseAdd BLAST329

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP67594
SMRiP67594
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi193 – 197"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

P67594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLFSGIQP SGIPTIGNYI GALKQFVDVQ NDYDCYFCIV DQHAITMPQD
60 70 80 90 100
RLKLRKQTRQ LAAIYLASGI DPDKATLFIQ SEVPAHVQAG WMLTTIASVG
110 120 130 140 150
ELERMTQYKD KAQKAVEGIP AGLLTYPPLM AADIVLYNTN IVPVGDDQKQ
160 170 180 190 200
HIELTRNLVD RFNSRYNDVL VKPEIRMPKV GGRVMSLQDP TRKMSKSDDN
210 220 230 240 250
AKNFISLLDE PNVAAKKIKS AVTDSDGIIK FDRDNKPGIT NLISIYAGLT
260 270 280 290 300
DMPIKDIEAK YEGEGYGKFK GDLAEIVKAF LVEFQEKYES FYNSDKLDDI
310 320
LDQGRDKAHK VSFKTVKKME KAMGLGRKR
Length:329
Mass (Da):36,909
Last modified:October 11, 2004 - v1
Checksum:i5F55F1B897FA0291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA Translation: BAB94743.1
RefSeqiWP_000448934.1, NC_003923.1

Genome annotation databases

EnsemblBacteriaiBAB94743; BAB94743; BAB94743
KEGGisam:MW0878

Similar proteinsi

Entry informationi

Entry nameiSYW_STAAW
AccessioniPrimary (citable) accession number: P67594
Secondary accession number(s): Q99V94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health