P67548 (PSD_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	Mb0445c

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029781
	Chain	200 – 231	32	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029782
Sites
	Site	199 – 200	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	200	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P67548 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: EA9C65BD41A579B3	FASTA	231	24,260
	10 20 30 40 50 60 MARRPRPDGP QHLLALVRSA VPPVHPAGRP FIAAGLAIAA VGHRYRWLRG TGLLAAAACA 70 80 90 100 110 120 GFFRHPQRVP PTRPAAIVAP ADGVICAIDS AAPPAELSMG DTPLPRVSIF LSILDAHVQR 130 140 150 160 170 180 APVSGEVIAV QHRPGRFGSA DLPEASDDNE RTSVRIRMPN GAEVVAVQIA GLVARRIVCD 190 200 210 220 230 AHVGDKLAIG DTYGLIRFGS RLDTYLPAGA EPIVNVGQRA VAGETVLAEC R

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248335 Genomic DNA. Translation: CAD93308.1.
RefSeq	NP_854108.1. NC_002945.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000016844; EBMYCP00000016679; EBMYCG00000016839.
GeneID	1091463.
GenomeReviews	Gene locus Mb0445c in contig BX248333_GR.
KEGG	mbo:Mb0445c.
PATRIC	18002633. VBIMycBov88188_0485.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017584.
HOGENOM	HBG541103.
OMA	IFMSVFN.
ProtClustDB	PRK05305.
Enzyme and pathway databases
BioCyc	MBOV233413:MB0445C-MONOMER.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase-related. [Graphical view]
KO	K01613.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_MYCBO

Accession

Primary (citable) accession number: P67548
Secondary accession number(s): O86324

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program