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P67547 (PSD_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:Rv0437c, MT0453
ORF Names:MTV037.01c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentplasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000029779
Chain200 – 23132Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000029780

Sites

Site199 – 2002Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2001Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
P67547 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: EA9C65BD41A579B3

FASTA23124,260
        10         20         30         40         50         60 
MARRPRPDGP QHLLALVRSA VPPVHPAGRP FIAAGLAIAA VGHRYRWLRG TGLLAAAACA 

        70         80         90        100        110        120 
GFFRHPQRVP PTRPAAIVAP ADGVICAIDS AAPPAELSMG DTPLPRVSIF LSILDAHVQR 

       130        140        150        160        170        180 
APVSGEVIAV QHRPGRFGSA DLPEASDDNE RTSVRIRMPN GAEVVAVQIA GLVARRIVCD 

       190        200        210        220        230 
AHVGDKLAIG DTYGLIRFGS RLDTYLPAGA EPIVNVGQRA VAGETVLAEC R

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842573 Genomic DNA. Translation: CAB06588.1.
AE000516 Genomic DNA. Translation: AAK44676.1.
PIRC70632.
RefSeqNP_214951.1. NC_000962.2.
NP_334862.1. NC_002755.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000000177; EBMYCP00000000177; EBMYCG00000000177.
EBMYCT00000071927; EBMYCP00000069986; EBMYCG00000071922.
GeneID886350.
923771.
GenomeReviewsGene locus MT0453 in contig AE000516_GR.
Gene locus Rv0437c in contig AL123456_GR.
KEGGmtc:MT0453.
mtu:Rv0437c.
PATRIC18122706. VBIMycTub22151_0487.
TIGRMT0453.

Organism-specific databases

TubercuListRv0437c.

Phylogenomic databases

GeneTreeEBGT00050000017584.
HOGENOMHBG541103.
OMAIFMSVFN.
PhylomeDBP67547.
ProtClustDBPRK05305.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_MYCTU
AccessionPrimary (citable) accession number: P67547
Secondary accession number(s): O86324
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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