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P67542

- PUR9_MYCBO

UniProt

P67542 - PUR9_MYCBO

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Mb0982
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Bifunctional purine biosynthesis protein PurHPRO_0000192107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb0982.

Structurei

3D structure databases

ProteinModelPortaliP67542.
SMRiP67542. Positions 4-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

Sequence similaritiesi

Belongs to the PurH family.Curated

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

P67542-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTDDGRRPI RRALISVYDK TGLVDLAQGL SAAGVEIIST GSTAKTIADT
60 70 80 90 100
GIPVTPVEQL TGFPEVLDGR VKTLHPRVHA GLLADLRKSE HAAALEQLGI
110 120 130 140 150
EAFELVVVNL YPFSQTVESG ASVDDCVEQI DIGGPAMVRA AAKNHPSAAV
160 170 180 190 200
VTDPLGYHGV LAALRAGGFT LAERKRLASL AFQHIAEYDI AVASWMQQTL
210 220 230 240 250
APEHPVAAFP QWFGRSWRRV AMLRYGENPH QQAALYGDPT AWPGLAQAEQ
260 270 280 290 300
LHGKDMSYNN FTDADAAWRA AFDHEQTCVA IIKHANPCGI AISSVSVADA
310 320 330 340 350
HRKAHECDPL SAYGGVIAAN TEVSVEMAEY VSTIFTEVIV APGYAPGALD
360 370 380 390 400
VLARKKNIRV LVAAEPLAGG SELRPISGGL LIQQSDQLDA HGDNPANWTL
410 420 430 440 450
ATGSPADPAT LTDLVFAWRA CRAVKSNAIV IAADGATVGV GMGQVNRVDA
460 470 480 490 500
ARLAVERGGE RVRGAVAASD AFFPFPDGLE TLAAAGVTAV VHPGGSVRDE
510 520
EVTEAAAKAG VTLYLTGARH FAH
Length:523
Mass (Da):55,026
Last modified:October 11, 2004 - v1
Checksum:i5A78C034101019C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42226.1.
RefSeqiNP_854639.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD93843; CAD93843; Mb0982.
GeneIDi1093066.
KEGGimbo:Mb0982.
PATRICi18003825. VBIMycBov88188_1069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42226.1 .
RefSeqi NP_854639.1. NC_002945.3.

3D structure databases

ProteinModelPortali P67542.
SMRi P67542. Positions 4-523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb0982.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD93843 ; CAD93843 ; Mb0982 .
GeneIDi 1093066.
KEGGi mbo:Mb0982.
PATRICi 18003825. VBIMycBov88188_1069.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPUR9_MYCBO
AccessioniPrimary (citable) accession number: P67542
Secondary accession number(s): P71553, X2BGN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3