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P67541 (PUR9_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Rv0957, MT0984
ORF Names:MTCY10D7.17c
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192106

Secondary structure

1 ................................................................................................... 523
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P67541 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5A78C034101019C7

FASTA52355,026
        10         20         30         40         50         60 
MSTDDGRRPI RRALISVYDK TGLVDLAQGL SAAGVEIIST GSTAKTIADT GIPVTPVEQL 

        70         80         90        100        110        120 
TGFPEVLDGR VKTLHPRVHA GLLADLRKSE HAAALEQLGI EAFELVVVNL YPFSQTVESG 

       130        140        150        160        170        180 
ASVDDCVEQI DIGGPAMVRA AAKNHPSAAV VTDPLGYHGV LAALRAGGFT LAERKRLASL 

       190        200        210        220        230        240 
AFQHIAEYDI AVASWMQQTL APEHPVAAFP QWFGRSWRRV AMLRYGENPH QQAALYGDPT 

       250        260        270        280        290        300 
AWPGLAQAEQ LHGKDMSYNN FTDADAAWRA AFDHEQTCVA IIKHANPCGI AISSVSVADA 

       310        320        330        340        350        360 
HRKAHECDPL SAYGGVIAAN TEVSVEMAEY VSTIFTEVIV APGYAPGALD VLARKKNIRV 

       370        380        390        400        410        420 
LVAAEPLAGG SELRPISGGL LIQQSDQLDA HGDNPANWTL ATGSPADPAT LTDLVFAWRA 

       430        440        450        460        470        480 
CRAVKSNAIV IAADGATVGV GMGQVNRVDA ARLAVERGGE RVRGAVAASD AFFPFPDGLE 

       490        500        510        520 
TLAAAGVTAV VHPGGSVRDE EVTEAAAKAG VTLYLTGARH FAH

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842575 Genomic DNA. Translation: CAB01993.1.
AE000516 Genomic DNA. Translation: AAK45232.1.
AL123456 Genomic DNA. Translation: CCP43705.1.
PIRC70717.
RefSeqNP_215472.1. NC_000962.3.
NP_335418.1. NC_002755.2.
YP_006514314.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZZMX-ray2.20A/B1-523[»]
4A1OX-ray2.48A/B1-523[»]
ProteinModelPortalP67541.
SMRP67541. Positions 4-523.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv0957.

Proteomic databases

PRIDEP67541.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK45232; AAK45232; MT0984.
GeneID13319514.
885406.
926376.
KEGGmtc:MT0984.
mtu:Rv0957.
mtv:RVBD_0957.
PATRIC18123908. VBIMycTub22151_1077.

Organism-specific databases

TubercuListRv0957.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
ProtClustDBPRK00881.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF53927. Cytidine_deaminase-like. 1 hit.
SSF52335. MGS-like_dom. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP67541.

Entry information

Entry namePUR9_MYCTU
AccessionPrimary (citable) accession number: P67541
Secondary accession number(s): L0T5A3, P71553
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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