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Reviewed, UniProtKB/Swiss-Prot P67516 (RLMH_BRUME)

Last modified November 24, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ribosomal RNA large subunit methyltransferase H
    EC=2.1.1.-
Alternative name(s):
    rRNA (pseudouridine-N3-)-methyltransferase rlmH
    23S rRNA m3Psi1915 methyltransferase
Gene names
Name: rlmH
Ordered Locus Names: BMEI0211
OrganismBrucella melitensis [Complete proteome] [HAMAP]
Taxonomic identifier29459 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA By similarity.

Catalytic activity

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine. HAMAP MF_00658

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the RNA methyltransferase rlmH family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processrRNA methylation

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionrRNA (pseudouridine-N3-)-methyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 174174Ribosomal RNA large subunit methyltransferase H HAMAP MF_00658
PRO_0000198102

Sequences

Sequence LengthMass (Da)Tools
P67516-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 6888974DB99771A6

FASTA17418,649
        10         20         30         40         50         60 
MRVSVFAVGR MKSGPERELV ERYFDRFAKA GPPLGLEFAG VSEIPESRGQ TAQLRKAEEA 

        70         80         90        100        110        120 
QRIHEALDNA KSGGAKSGGT SSGGAALILL DERGKTLGSE AFAAIVGRMR DDGKRQLIVA 

       130        140        150        160        170 
IGGPDGHDPA LRSRADLVLA LGELTWPHQI ARILIAEQLY RAATILAGHP YHRS 

« Hide

Cross-references

Sequence databases

AE008917 Genomic DNA. Translation: AAL51393.1.
PIRAF3278.
RefSeqNP_539129.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1195923.
GenomeReviewsGene locus BMEI0211 in contig AE008917_GR.
KEGGbme:BMEI0211.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP67516.
OMAILSGHPY

Enzyme and pathway databases

BioCycBMEL224914:BMEI0211-MON.

Family and domain databases

HAMAPMF_00658.
[Tree]
InterProIPR003742. SPOUT_MeTrfase.
[Graphical view]
PfamPF02590. SPOUT_MTase. 1 hit.
[Graphical view]
PIRSFPIRSF004505. MT_bac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRLMH_BRUME
AccessionPrimary (citable) accession number: P67516
Secondary accession number(s): Q8FYM5, Q8YJ75
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 24, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents