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P67516

- RLMH_BRUME

UniProt

P67516 - RLMH_BRUME

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Protein

Ribosomal RNA large subunit methyltransferase H

Gene

rlmH

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine.
S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L-homocysteine + N(3)-methylpseudouridine(1915) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase HUniRule annotation (EC:2.1.1.177UniRule annotation)
Alternative name(s):
23S rRNA (pseudouridine1915-N3)-methyltransferaseUniRule annotation
23S rRNA m3Psi1915 methyltransferaseUniRule annotation
rRNA (pseudouridine-N3-)-methyltransferase RlmHUniRule annotation
Gene namesi
Name:rlmHUniRule annotation
Ordered Locus Names:BMEI0211
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 174174Ribosomal RNA large subunit methyltransferase HPRO_0000198102Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI0211.

Structurei

3D structure databases

ProteinModelPortaliP67516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA methyltransferase RlmH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218433.
KOiK00783.
OMAiSVIAMEV.
OrthoDBiEOG6S26HR.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00658. 23SrRNA_methyltr_H.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR003742. SPOUT_MeTrfase.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF02590. SPOUT_MTase. 1 hit.
[Graphical view]
PIRSFiPIRSF004505. MT_bac. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.

Sequencei

Sequence statusi: Complete.

P67516-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVSVFAVGR MKSGPERELV ERYFDRFAKA GPPLGLEFAG VSEIPESRGQ
60 70 80 90 100
TAQLRKAEEA QRIHEALDNA KSGGAKSGGT SSGGAALILL DERGKTLGSE
110 120 130 140 150
AFAAIVGRMR DDGKRQLIVA IGGPDGHDPA LRSRADLVLA LGELTWPHQI
160 170
ARILIAEQLY RAATILAGHP YHRS
Length:174
Mass (Da):18,649
Last modified:October 11, 2004 - v1
Checksum:i6888974DB99771A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL51393.1.
PIRiAF3278.
RefSeqiNP_539129.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL51393; AAL51393; BMEI0211.
GeneIDi1195923.
KEGGibme:BMEI0211.
PATRICi17802032. VBIBruMel146950_3333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL51393.1 .
PIRi AF3278.
RefSeqi NP_539129.1. NC_003317.1.

3D structure databases

ProteinModelPortali P67516.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL51393 ; AAL51393 ; BMEI0211 .
GeneIDi 1195923.
KEGGi bme:BMEI0211.
PATRICi 17802032. VBIBruMel146950_3333.

Phylogenomic databases

HOGENOMi HOG000218433.
KOi K00783.
OMAi SVIAMEV.
OrthoDBi EOG6S26HR.

Family and domain databases

Gene3Di 3.40.1280.10. 1 hit.
HAMAPi MF_00658. 23SrRNA_methyltr_H.
InterProi IPR029028. Alpha/beta_knot_MTases.
IPR003742. SPOUT_MeTrfase.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view ]
Pfami PF02590. SPOUT_MTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004505. MT_bac. 1 hit.
SUPFAMi SSF75217. SSF75217. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiRLMH_BRUME
AccessioniPrimary (citable) accession number: P67516
Secondary accession number(s): Q8FYM5, Q8YJ75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3