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P67516

- RLMH_BRUME

UniProt

P67516 - RLMH_BRUME

Protein

Ribosomal RNA large subunit methyltransferase H

Gene

rlmH

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine.
    S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L-homocysteine + N(3)-methylpseudouridine(1915) in 23S rRNA.UniRule annotation

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase HUniRule annotation (EC:2.1.1.177UniRule annotation)
    Alternative name(s):
    23S rRNA (pseudouridine1915-N3)-methyltransferaseUniRule annotation
    23S rRNA m3Psi1915 methyltransferaseUniRule annotation
    rRNA (pseudouridine-N3-)-methyltransferase RlmHUniRule annotation
    Gene namesi
    Name:rlmHUniRule annotation
    Ordered Locus Names:BMEI0211
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 174174Ribosomal RNA large subunit methyltransferase HPRO_0000198102Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI0211.

    Structurei

    3D structure databases

    ProteinModelPortaliP67516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA methyltransferase RlmH family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000218433.
    KOiK00783.
    OMAiSVIAMEV.
    OrthoDBiEOG6S26HR.

    Family and domain databases

    Gene3Di3.40.1280.10. 1 hit.
    HAMAPiMF_00658. 23SrRNA_methyltr_H.
    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR003742. SPOUT_MeTrfase.
    IPR029026. tRNA_m1G_MTases_N.
    [Graphical view]
    PfamiPF02590. SPOUT_MTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004505. MT_bac. 1 hit.
    SUPFAMiSSF75217. SSF75217. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P67516-1 [UniParc]FASTAAdd to Basket

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    MRVSVFAVGR MKSGPERELV ERYFDRFAKA GPPLGLEFAG VSEIPESRGQ    50
    TAQLRKAEEA QRIHEALDNA KSGGAKSGGT SSGGAALILL DERGKTLGSE 100
    AFAAIVGRMR DDGKRQLIVA IGGPDGHDPA LRSRADLVLA LGELTWPHQI 150
    ARILIAEQLY RAATILAGHP YHRS 174
    Length:174
    Mass (Da):18,649
    Last modified:October 11, 2004 - v1
    Checksum:i6888974DB99771A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51393.1.
    PIRiAF3278.
    RefSeqiNP_539129.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL51393; AAL51393; BMEI0211.
    GeneIDi1195923.
    KEGGibme:BMEI0211.
    PATRICi17802032. VBIBruMel146950_3333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51393.1 .
    PIRi AF3278.
    RefSeqi NP_539129.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali P67516.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0211.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL51393 ; AAL51393 ; BMEI0211 .
    GeneIDi 1195923.
    KEGGi bme:BMEI0211.
    PATRICi 17802032. VBIBruMel146950_3333.

    Phylogenomic databases

    HOGENOMi HOG000218433.
    KOi K00783.
    OMAi SVIAMEV.
    OrthoDBi EOG6S26HR.

    Family and domain databases

    Gene3Di 3.40.1280.10. 1 hit.
    HAMAPi MF_00658. 23SrRNA_methyltr_H.
    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR003742. SPOUT_MeTrfase.
    IPR029026. tRNA_m1G_MTases_N.
    [Graphical view ]
    Pfami PF02590. SPOUT_MTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004505. MT_bac. 1 hit.
    SUPFAMi SSF75217. SSF75217. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiRLMH_BRUME
    AccessioniPrimary (citable) accession number: P67516
    Secondary accession number(s): Q8FYM5, Q8YJ75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3