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P67516 (RLMH_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal RNA large subunit methyltransferase H

EC=2.1.1.177
Alternative name(s):
23S rRNA (pseudouridine1915-N3)-methyltransferase
23S rRNA m3Psi1915 methyltransferase
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Gene names
Name:rlmH
Ordered Locus Names:BMEI0211
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA By similarity. HAMAP-Rule MF_00658

Catalytic activity

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine. HAMAP-Rule MF_00658

S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L-homocysteine + N(3)-methylpseudouridine(1915) in 23S rRNA. HAMAP-Rule MF_00658

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00658

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00658.

Sequence similarities

Belongs to the RNA methyltransferase RlmH family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 174174Ribosomal RNA large subunit methyltransferase H HAMAP-Rule MF_00658
PRO_0000198102

Sequences

Sequence LengthMass (Da)Tools
P67516 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 6888974DB99771A6

FASTA17418,649
        10         20         30         40         50         60 
MRVSVFAVGR MKSGPERELV ERYFDRFAKA GPPLGLEFAG VSEIPESRGQ TAQLRKAEEA 

        70         80         90        100        110        120 
QRIHEALDNA KSGGAKSGGT SSGGAALILL DERGKTLGSE AFAAIVGRMR DDGKRQLIVA 

       130        140        150        160        170 
IGGPDGHDPA LRSRADLVLA LGELTWPHQI ARILIAEQLY RAATILAGHP YHRS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL51393.1.
PIRAF3278.
RefSeqNP_539129.1. NC_003317.1.

3D structure databases

ProteinModelPortalP67516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI0211.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL51393; AAL51393; BMEI0211.
GeneID1195923.
KEGGbme:BMEI0211.
PATRIC17802032. VBIBruMel146950_3333.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000218433.
KOK00783.
OMASVIAMEV.
OrthoDBEOG6S26HR.

Family and domain databases

Gene3D3.40.1280.10. 1 hit.
HAMAPMF_00658. 23SrRNA_methyltr_H.
InterProIPR029028. Alpha/beta_knot_MTases.
IPR003742. SPOUT_MeTrfase.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamPF02590. SPOUT_MTase. 1 hit.
[Graphical view]
PIRSFPIRSF004505. MT_bac. 1 hit.
SUPFAMSSF75217. SSF75217. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRLMH_BRUME
AccessionPrimary (citable) accession number: P67516
Secondary accession number(s): Q8FYM5, Q8YJ75
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names