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P67478

- ALF2_STAAW

UniProt

P67478 - ALF2_STAAW

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Glyceraldehyde 3-phosphateBy similarity
Active sitei85 – 851Proton donorBy similarity
Metal bindingi86 – 861Zinc 1; catalyticBy similarity
Metal bindingi107 – 1071Zinc 2By similarity
Metal bindingi137 – 1371Zinc 2By similarity
Metal bindingi181 – 1811Zinc 1; catalyticBy similarity
Binding sitei182 – 1821Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi209 – 2091Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2118-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:fbaA
Ordered Locus Names:MW2049
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Fructose-bisphosphate aldolasePRO_0000178740Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196620.MW2049.

Structurei

3D structure databases

ProteinModelPortaliP67478.
SMRiP67478. Positions 1-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2123Dihydroxyacetone phosphate bindingBy similarity
Regioni231 – 2344Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227793.
KOiK01624.
OMAiDCRMALT.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P67478-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLVSMKEML IDAKENGYAV GQYNINNLEF TQAILEASQE ENAPVILGVS
60 70 80 90 100
EGAARYMSGF YTIVKMVEGL MHDLNITIPV AIHLDHGSSF EKCKEAIDAG
110 120 130 140 150
FTSVMIDASH SPFEENVATT KKVVEYAHEK GVSVEAELGT VGGQEDDVVA
160 170 180 190 200
DGIIYADPKE CQELVEKTGI DALAPALGSV HGPYKGEPKL GFKEMEEIGL
210 220 230 240 250
STGLPLVLHG GTGIPTKDIQ KAIPFGTAKI NVNTENQIAS AKAVRDVLNN
260 270 280
DKEVYDPRKY LGPAREAIKE TVKGKIKEFG TSNRAK
Length:286
Mass (Da):30,836
Last modified:October 11, 2004 - v1
Checksum:i7A5FD0EBD48283D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95914.1.
RefSeqiNP_646866.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95914; BAB95914; BAB95914.
GeneIDi1004165.
KEGGisam:MW2049.
PATRICi19570812. VBIStaAur44266_2124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95914.1 .
RefSeqi NP_646866.1. NC_003923.1.

3D structure databases

ProteinModelPortali P67478.
SMRi P67478. Positions 1-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW2049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB95914 ; BAB95914 ; BAB95914 .
GeneIDi 1004165.
KEGGi sam:MW2049.
PATRICi 19570812. VBIStaAur44266_2124.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227793.
KOi K01624.
OMAi DCRMALT.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci SAUR196620:GJ9Z-2118-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiALF2_STAAW
AccessioniPrimary (citable) accession number: P67478
Secondary accession number(s): Q99SD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3