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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei795-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei1045-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei194Uracil; via amide nitrogenUniRule annotation1
Binding sitei2005-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:MW2036
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001208841 – 209Uracil phosphoribosyltransferaseAdd BLAST209

Structurei

3D structure databases

ProteinModelPortaliP67397
SMRiP67397
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 1395-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation9
Regioni199 – 201Uracil bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262754
KOiK00761
OMAiRICGYEI

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit

Sequencei

Sequence statusi: Complete.

P67397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVHVFDHP LIQHKLSYIR DVNTGTKEFR ELVDEVGMLM AYEVTRDLEL
60 70 80 90 100
QDVDIETPVT KMTAKRLAGK KLAIVPILRA GLGMTDGILS LVPAARVGHI
110 120 130 140 150
GLYRDPETLK AVEYFAKLPQ DITERQIIVV DPMLATGASA IEAITSLKKR
160 170 180 190 200
GAKNIRFMCL IAAPEGVEKM HEAHPDVDIY IAALDEKLND KAYITPGLGD

AGDRLFGTK
Length:209
Mass (Da):23,050
Last modified:October 11, 2004 - v1
Checksum:i4D876B29317CE3B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA Translation: BAB95901.1
RefSeqiWP_000048712.1, NC_003923.1

Genome annotation databases

EnsemblBacteriaiBAB95901; BAB95901; BAB95901
KEGGisam:MW2036

Similar proteinsi

Entry informationi

Entry nameiUPP_STAAW
AccessioniPrimary (citable) accession number: P67397
Secondary accession number(s): P58999, Q99SE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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