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P67394

- UPPP_STRP8

UniProt

P67394 - UPPP_STRP8

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, bacA, upk, spyM18_0268
Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPYO186103:GHJG-259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:spyM18_0268
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000820: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed predictionAdd
BLAST
Transmembranei44 – 6421Helical; Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Transmembranei113 – 13321Helical; Reviewed predictionAdd
BLAST
Transmembranei163 – 18321Helical; Reviewed predictionAdd
BLAST
Transmembranei188 – 20821Helical; Reviewed predictionAdd
BLAST
Transmembranei223 – 24321Helical; Reviewed predictionAdd
BLAST
Transmembranei255 – 27521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Undecaprenyl-diphosphataseUniRule annotationPRO_0000151219Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi186103.spyM18_0268.

Structurei

3D structure databases

ProteinModelPortaliP67394.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P67394-1 [UniParc]FASTAAdd to Basket

« Hide

MLIIELLKAI FFGIIEGITE WLPVSSTGHL ILVQEFIRLN QDKAFIEMFN    50
IVIQLGAIIA VMLIYFERLN PFQPGKTARE VQLTWQLWLK VVIACIPSIL 100
IAVPLDNWFE AHFYFMVPIA IALIVYGIAF IWIEKRNAQQ EPAVTELARM 150
SYKTAFFIGC FQVLSIVPGT SRSGATILGA IILGTSRTVA ADFTFFLAIP 200
TMFGYSGLKA VKFFLDGHHL DFAQVLILLV ASLTAFVVSL LAIRFLTDYV 250
KKHDFTIFGK YRIVLGSLLL IYSFFKFVF 279
Length:279
Mass (Da):31,538
Last modified:October 11, 2004 - v1
Checksum:iAB0EC20DBD1B8A30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL97046.1.
RefSeqiNP_606547.1. NC_003485.1.

Genome annotation databases

EnsemblBacteriaiAAL97046; AAL97046; spyM18_0268.
GeneIDi993650.
KEGGispm:spyM18_0268.
PATRICi19747262. VBIStrPyo4396_0230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL97046.1 .
RefSeqi NP_606547.1. NC_003485.1.

3D structure databases

ProteinModelPortali P67394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186103.spyM18_0268.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL97046 ; AAL97046 ; spyM18_0268 .
GeneIDi 993650.
KEGGi spm:spyM18_0268.
PATRICi 19747262. VBIStrPyo4396_0230.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci SPYO186103:GHJG-259-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."
    Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS8232.

Entry informationi

Entry nameiUPPP_STRP8
AccessioniPrimary (citable) accession number: P67394
Secondary accession number(s): Q9A1G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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