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P67392 (UPPP_STRP1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:SPy_0280, M5005_Spy0238
OrganismStreptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]
Taxonomic identifier301447 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151216

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane44 – 6421Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane223 – 24321Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P67392 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: AB0EC20DBD1B8A30

FASTA27931,538
        10         20         30         40         50         60 
MLIIELLKAI FFGIIEGITE WLPVSSTGHL ILVQEFIRLN QDKAFIEMFN IVIQLGAIIA 

        70         80         90        100        110        120 
VMLIYFERLN PFQPGKTARE VQLTWQLWLK VVIACIPSIL IAVPLDNWFE AHFYFMVPIA 

       130        140        150        160        170        180 
IALIVYGIAF IWIEKRNAQQ EPAVTELARM SYKTAFFIGC FQVLSIVPGT SRSGATILGA 

       190        200        210        220        230        240 
IILGTSRTVA ADFTFFLAIP TMFGYSGLKA VKFFLDGHHL DFAQVLILLV ASLTAFVVSL 

       250        260        270 
LAIRFLTDYV KKHDFTIFGK YRIVLGSLLL IYSFFKFVF 

« Hide

References

[1]"Complete genome sequence of an M1 strain of Streptococcus pyogenes."
Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. expand/collapse author list , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E.
Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700294 / SF370 / Serotype M1.
[2]"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004092 Genomic DNA. Translation: AAK33352.1.
CP000017 Genomic DNA. Translation: AAZ50857.1.
RefSeqNP_268631.1. NC_002737.1.
YP_281602.1. NC_007297.1.

3D structure databases

ProteinModelPortalP67392.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160490.SPy_0280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK33352; AAK33352; SPy_0280.
AAZ50857; AAZ50857; M5005_Spy0238.
GeneID3572666.
900577.
KEGGspy:SPy_0280.
spz:M5005_Spy_0238.
PATRIC19714343. VBIStrPyo79812_0246.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAMILVEEF.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSPYO160490:GJ81-255-MONOMER.
SPYO293653:GHFC-288-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_STRP1
AccessionPrimary (citable) accession number: P67392
Secondary accession number(s): Q490W1, Q9A1G8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families