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P67391

- UPPP_STAAN

UniProt

P67391 - UPPP_STAAN

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-674-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:SA0638
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Undecaprenyl-diphosphatasePRO_0000151200Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi158879.SA0638.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei48 – 6821HelicalUniRule annotationAdd
    BLAST
    Transmembranei102 – 12221HelicalUniRule annotationAdd
    BLAST
    Transmembranei126 – 14621HelicalUniRule annotationAdd
    BLAST
    Transmembranei162 – 18221HelicalUniRule annotationAdd
    BLAST
    Transmembranei203 – 22321HelicalUniRule annotationAdd
    BLAST
    Transmembranei231 – 25121HelicalUniRule annotationAdd
    BLAST
    Transmembranei267 – 28721HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P67391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFIIELIKGI ILGVVEGLTE FAPVSSTGHM ILVDDMWLKS SEFLGSQSAF    50
    TFKIVIQLGS VFAAAWVFRE RFLEILHIGK HKHVEGENDQ QRRSKPRRLN 100
    LLHVLVGMVP AGILGLLFDD FIEEHLFSVP TVMIGLFVGA IYMIIADKYS 150
    VKVKNPQTVD QINYFQAFVI GISQAVAMWP GFSRSGSTIS TGVLMKLNHK 200
    AASDFTFIMA VPIMLAASGL SLLKHYQDIQ IADIPFYILG FLAAFTVGLI 250
    AIKTFLHLIN KIKLIPFAIY RIVLVIFIAI LYFGFGIGKG I 291
    Length:291
    Mass (Da):32,339
    Last modified:October 11, 2004 - v1
    Checksum:i33A3DAC498FDFD9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB41871.1.
    PIRiD89839.
    RefSeqiNP_373893.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB41871; BAB41871; BAB41871.
    GeneIDi1123445.
    KEGGisau:SA0638.
    PATRICi19573398. VBIStaAur116463_0669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB41871.1 .
    PIRi D89839.
    RefSeqi NP_373893.1. NC_002745.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA0638.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB41871 ; BAB41871 ; BAB41871 .
    GeneIDi 1123445.
    KEGGi sau:SA0638.
    PATRICi 19573398. VBIStaAur116463_0669.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SAUR158879:GJCB-674-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.

    Entry informationi

    Entry nameiUPPP_STAAN
    AccessioniPrimary (citable) accession number: P67391
    Secondary accession number(s): Q99VT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3