P67322 (NRDR_STRP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional repressor NrdR

Gene names

Name:	nrdR
Ordered Locus Names:	spyM18_0330

Organism

Streptococcus pyogenes serotype M18 (strain MGAS8232) [Complete proteome] [HAMAP]

Taxonomic identifier

186103 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Streptococcus pyogenes serotype M18

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes By similarity. HAMAP-Rule MF_00440
Cofactor	Binds 1 zinc ion By similarity.
Sequence similarities	Belongs to the NrdR family. Contains 1 ATP-cone domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Domain	Zinc-finger
Ligand	ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Transcriptional repressor NrdR HAMAP-Rule MF_00440		PRO_0000182360
Regions
	Domain	49 – 139	91	ATP-cone
	Zinc finger	3 – 34	32	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P67322 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 7CCDEBE6F10BE262	FASTA	164	19,131
	10 20 30 40 50 60 MRCPKCNYHK SSVVDSRQAE DGNTIRRRRE CEQCHTRFTT FERVEELPLL VIKKDGTREQ 70 80 90 100 110 120 FSRDKILNGV VQSAQKRPVS STDIENVISR IEQEVRTTYE NEVSSTAIGN LVMDELAELD 130 140 150 160 EITYVRFASV YKSFKDVDEI EELLQQITNR VRGKKKRLNN DETN

References

[1]

"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks." Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS8232.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009949 Genomic DNA. Translation: AAL97085.1.
RefSeq	NP_606586.1. NC_003485.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	186103.spyM18_0330.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL97085; AAL97085; spyM18_0330.
GeneID	995007.
KEGG	spm:spyM18_0330.
PATRIC	19747360. VBIStrPyo4396_0273.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1327.
HOGENOM	HOG000097653.
KO	K07738.
OMA	VCHERFT.
ProtClustDB	PRK00464.
Family and domain databases
HAMAP	MF_00440. NrdR.
InterPro	IPR005144. ATP-cone. IPR003796. RNR_NrdR-like. [Graphical view]
Pfam	PF03477. ATP-cone. 1 hit. [Graphical view]
TIGRFAMs	TIGR00244. TIGR00244. 1 hit.
PROSITE	PS51161. ATP_CONE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NRDR_STRP8

Accession

Primary (citable) accession number: P67322
Secondary accession number(s): Q9A1D3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program