P67133 (YBEY_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endoribonuclease YbeY
EC=3.1.-.-

Gene names

Name:	ybeY
Ordered Locus Names:	BR2156, BS1330_I2150

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA By similarity. HAMAP-Rule MF_00009
Cofactor	Binds 1 zinc ion By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the endoribonuclease YbeY family.
Sequence caution	The sequence AAN31046.1 differs from that shown. Reason: Erroneous initiation. The sequence AEM19463.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC rRNA processing Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	endoribonuclease activity Inferred from electronic annotation. Source: HAMAP metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Endoribonuclease YbeY HAMAP-Rule MF_00009		PRO_0000102424
Sites
	Metal binding	122	1	Zinc; catalytic By similarity
	Metal binding	126	1	Zinc; catalytic By similarity
	Metal binding	132	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P67133 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: BC6B2B7F0F074795	FASTA	168	18,423
	10 20 30 40 50 60 MSDNAIHIDI MIEAGNWPDE ASLESLVSKS VAAAWNNLGL KSATSELSVV FTDDASIQLL 70 80 90 100 110 120 NGEWRGKDKP TNVLSFPAFP VKAGSQPGPM LGDIVIARET VEREAKEEGK PIENHLSHLV 130 140 150 160 VHGFLHLLGY DHETDEEAEV MEAREREILH ALAIPDPYAV SDEDINND

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN31046.1. Different initiation. CP002997 Genomic DNA. Translation: AEM19463.1. Different initiation.
RefSeq	NP_699131.1. NC_004310.3. YP_005616955.1. NC_017251.1.
3D structure databases
ProteinModelPortal	P67133.
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BR2156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN31046; AAN31046; BR2156. AEM19463; AEM19463; BS1330_I2150.
GeneID	1167859. 12138579.
KEGG	bms:BR2156. bsi:BS1330_I2150.
PATRIC	17792745. VBIBruSui107850_2193.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0319.
HOGENOM	HOG000132869.
KO	K07042.
ProtClustDB	CLSK864324.
Family and domain databases
Gene3D	3.40.390.30. 1 hit.
HAMAP	MF_00009. Endoribonucl_YbeY.
InterPro	IPR023091. MetalPrtase_cat_dom_prd. IPR020549. UPF0054_CS. IPR002036. UPF0054_metalloprotease_prd. [Graphical view]
Pfam	PF02130. UPF0054. 1 hit. [Graphical view]
TIGRFAMs	TIGR00043. TIGR00043. 1 hit.
PROSITE	PS01306. UPF0054. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YBEY_BRUSU

Accession

Primary (citable) accession number: P67133
Secondary accession number(s): G0K9I2, Q8FXU1, Q8YEA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program