Reviewed, UniProtKB/Swiss-Prot P67083 (Y2148_MYCTU)

Names and origin

Protein names

Recommended name:
    UPF0001 protein Rv2148c/MT2207

Gene names

Ordered Locus Names:	Rv2148c, MT2207
ORF Names:	MTCY270.20

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the UPF0001 family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	UPF0001 protein Rv2148c/MT2207		PRO_0000163203
Amino acid modifications
	Modified residue	47	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P67083-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 6C534D96E9368BB2	FASTA	258	27,693
	10 20 30 40 50 60 MAADLSAYPD RESELTHALA AMRSRLAAAA EAAGRNVGEI ELLPITKFFP ATDVAILFRL 70 80 90 100 110 120 GCRSVGESRE QEASAKMAEL NRLLAAAELG HSGGVHWHMV GRIQRNKAGS LARWAHTAHS 130 140 150 160 170 180 VDSSRLVTAL DRAVVAALAE HRRGERLRVY VQVSLDGDGS RGGVDSTTPG AVDRICAQVQ 190 200 210 220 230 240 ESEGLELVGL MGIPPLDWDP DEAFDRLQSE HNRVRAMFPH AIGLSAGMSN DLEVAVKHGS 250 TCVRVGTALL GPRRLRSP

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842578 Genomic DNA. Translation: CAB08645.1. AE000516 Genomic DNA. Translation: AAK46491.1. Different initiation.
PIR	H70578.
RefSeq	NP_216664.1. NP_336677.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	888127. 924254.
GenomeReviews	Gene locus MT2207 in contig AE000516_GR. Gene locus Rv2148c in contig AL123456_GR.
KEGG	mtc:MT2207. mtu:Rv2148c.
TIGR	MT2207.
Organism-specific databases
TubercuList	Rv2148c.
Phylogenomic databases
HOGENOM	P67083.
OMA	AENREQE
Family and domain databases
InterPro	IPR001608. Ala_racemase_N. IPR011078. Prd-pyrdxlP-dep_enz_YBL036C. [Graphical view]
PANTHER	PTHR10146. PP_YBL036C. 1 hit.
Pfam	PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PIRSF	PIRSF004848. YBL036c_PLPDEIII. 1 hit.
TIGRFAMs	TIGR00044. PP_YBL036C. 1 hit.
PROSITE	PS01211. UPF0001. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y2148_MYCTU

Accession

Primary (citable) accession number: P67083
Secondary accession number(s): O06228

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)