P67075 (UNG_STAAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uracil-DNA glycosylase
Short name=UDG
EC=3.2.2.27

Gene names

Name:	ung
Ordered Locus Names:	SAV0581

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity. HAMAP MF_00148
Catalytic activity	Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. HAMAP MF_00148
Subcellular location	Cytoplasm By similarity HAMAP MF_00148.
Sequence similarities	Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	base-excision repair Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uracil DNA N-glycosylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Uracil-DNA glycosylase HAMAP MF_00148		PRO_0000176137
Sites
	Active site	59	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P67075 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 572AB88297F0D154	FASTA	218	24,937
	10 20 30 40 50 60 MEWSQIFHDI TTKHDFKAMH DFLEKEYSTA IVYPDRENIY QAFDLTPFEN IKVVILGQDP 70 80 90 100 110 120 YHGPNQAHGL AFSVQPNAKF PPSLRNMYKE LADDIGCVRQ TPHLQDWARE GVLLLNTVLT 130 140 150 160 170 180 VRQGEANSHR DIGWETFTDE IIKAVSDYKE HVVFILWGKP AQQKIKLIDT SKHCIIKSVH 190 200 210 PSPLSAYRGF FGSKPYSKAN AYLESVGKSP INWCESEA

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000017 Genomic DNA. Translation: BAB56743.1.
RefSeq	NP_371105.1. NC_002758.2.
3D structure databases
ProteinModelPortal	P67075.
SMR	P67075. Positions 2-214.
ModBase	Search...
Protein-protein interaction databases
STRING	P67075.
2D gel databases
World-2DPAGE	0002:P67075.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000007555; EBSTAP00000007373; EBSTAG00000007554.
GeneID	1120554.
GenomeReviews	Gene locus SAV0581 in contig BA000017_GR.
KEGG	sav:SAV0581.
PATRIC	19561814. VBIStaAur52173_0587.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0692.
GeneTree	EBGT00050000024952.
HOGENOM	HBG605450.
OMA	DIEPADH.
ProtClustDB	PRK05254.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV0581-MONOMER.
Family and domain databases
HAMAP	MF_00148. UDG. [Tree]
InterPro	IPR002043. UDNA_glycsylse. IPR018085. Ura-DNA_Glyclase_AS. IPR005122. Uracil-DNA_glycosylase-like. [Graphical view]
Gene3D	G3DSA:3.40.470.10. Uracil-DNA_glycosylase-like. 1 hit.
KO	K03648.
PANTHER	PTHR11264. UDNA_glycsylse. 1 hit.
Pfam	PF03167. UDG. 1 hit. [Graphical view]
SMART	SM00986. UDG. 1 hit. [Graphical view]
SUPFAM	SSF52141. UDNA_glycsylseSF. 1 hit.
TIGRFAMs	TIGR00628. Ung. 1 hit.
PROSITE	PS00130. U_DNA_GLYCOSYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UNG_STAAM

Accession

Primary (citable) accession number: P67075
Secondary accession number(s): Q99W30

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program