P67070 (HASC2_STRP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 2
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
UDP-glucose pyrophosphorylase 2
Short name=UDPGP 2
Uridine diphosphoglucose pyrophosphorylase 2

Gene names

Name:	hasC2
Synonyms:	hasC.2
Ordered Locus Names:	spyM18_0210

Organism

Streptococcus pyogenes serotype M18 (strain MGAS8232) [Complete proteome] [HAMAP]

Taxonomic identifier

186103 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Streptococcus pyogenes serotype M18

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	UTP--glucose-1-phosphate uridylyltransferase 2		PRO_0000201375

Sequences

	Sequence		Length	Mass (Da)
	P67070 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: D927314E58F6091B	FASTA	299	33,302
	10 20 30 40 50 60 MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILIVTGKS 70 80 90 100 110 120 KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF IRQSHPRGLG DAVLQAKTFV 130 140 150 160 170 180 GNEPFVVMLG DDLMDITNPN VKPLTKQLID DYEETHAATI AVMRVPHEDV SNYGIIAPQA 190 200 210 220 230 240 KAVKGLYSVD TFVEKPQPQD APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT 250 260 270 280 290 LNKTQRVFAR EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP

References

[1]

"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks." Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS8232.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009949 Genomic DNA. Translation: AAL97000.1.
RefSeq	NP_606501.1. NC_003485.1.
3D structure databases
ProteinModelPortal	P67070.
ModBase	Search...
Protein-protein interaction databases
STRING	186103.spyM18_0210.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL97000; AAL97000; spyM18_0210.
GeneID	995152.
KEGG	spm:spyM18_0210.
PATRIC	19747166. VBIStrPyo4396_0182.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000283477.
KO	K00963.
OMA	HETHAST.
ProtClustDB	CLSK877010.
Enzyme and pathway databases
BioCyc	SPYO186103:GHJG-213-MONOMER.
UniPathway	UPA00215.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HASC2_STRP8

Accession

Primary (citable) accession number: P67070
Secondary accession number(s): P58098

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 29, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program