Reviewed, UniProtKB/Swiss-Prot P67069 (HASC2_STRP3)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 2
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase 2
      Short name=UDPGP 2
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
    Uridine diphosphoglucose pyrophosphorylase 2

Gene names

Name:	hasC2
Synonyms:	hasC.2
Ordered Locus Names:	SpyM3_0160, SPs0166

Organism

Streptococcus pyogenes serotype M3 [Complete proteome] [HAMAP]

Taxonomic identifier

301448 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	UTP--glucose-1-phosphate uridylyltransferase 2		PRO_0000201373

Sequences

	Sequence		Length	Mass (Da)
	P67069-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: D927314E58F6091B	FASTA	299	33,302
	10 20 30 40 50 60 MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILIVTGKS 70 80 90 100 110 120 KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF IRQSHPRGLG DAVLQAKTFV 130 140 150 160 170 180 GNEPFVVMLG DDLMDITNPN VKPLTKQLID DYEETHAATI AVMRVPHEDV SNYGIIAPQA 190 200 210 220 230 240 KAVKGLYSVD TFVEKPQPQD APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT 250 260 270 280 290 LNKTQRVFAR EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP

References

[1]

"Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence." Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed: 12122206] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-595 / MGAS315 / Serotype M3.

[2]

"Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution." Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S. Genome Res. 13:1042-1055(2003) [PubMed: 12799345] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SSI-1 / Serotype M3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014074 Genomic DNA. Translation: AAM78767.1. BA000034 Genomic DNA. Translation: BAC63261.1. Different initiation.
RefSeq	NP_663964.1. NP_801428.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1008474. 1065625.
GenomeReviews	Gene locus SpyM3_0160 in contig AE014074_GR. Gene locus SPs0166 in contig BA000034_GR.
KEGG	spg:SpyM3_0160. sps:SPs0166.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P67069.
OMA	P67069. CIEDHFD.
Enzyme and pathway databases
BioCyc	SPYO193567:SPS0166-MON. SPYO198466:SPYM3_0160-MON.
Family and domain databases
InterPro	IPR005771. GalU_trans_bac. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HASC2_STRP3

Accession

Primary (citable) accession number: P67069
Secondary accession number(s): P58098

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)