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P67068

- HASC2_STRP1

UniProt

P67068 - HASC2_STRP1

Protein

UTP--glucose-1-phosphate uridylyltransferase 2

Gene

hasC2

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-211-MONOMER.
    SPYO293653:GHFC-242-MONOMER.
    UniPathwayiUPA00215.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 2 (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
    UDP-glucose pyrophosphorylase 2
    Short name:
    UDPGP 2
    Uridine diphosphoglucose pyrophosphorylase 2
    Gene namesi
    Name:hasC2
    Synonyms:hasC.2
    Ordered Locus Names:SPy_0224, M5005_Spy0192
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299UTP--glucose-1-phosphate uridylyltransferase 2PRO_0000201372Add
    BLAST

    Proteomic databases

    PaxDbiP67068.

    Interactioni

    Protein-protein interaction databases

    STRINGi160490.SPy_0224.

    Structurei

    3D structure databases

    ProteinModelPortaliP67068.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG1210.
    HOGENOMiHOG000283477.
    KOiK00963.
    OMAiYESTHAS.
    OrthoDBiEOG6Z9B3V.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01099. galU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P67068-1 [UniParc]FASTAAdd to Basket

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    MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI    50
    EEILIVTGKS KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF 100
    IRQSHPRGLG DAVLQAKTFV GNEPFVVMLG DDLMDITNPN VKPLTKQLID 150
    DYEETHAATI AVMRVPHEDV SNYGIIAPQA KAVKGLYSVD TFVEKPQPQD 200
    APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT LNKTQRVFAR 250
    EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP 299
    Length:299
    Mass (Da):33,302
    Last modified:October 11, 2004 - v1
    Checksum:iD927314E58F6091B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33308.1.
    CP000017 Genomic DNA. Translation: AAZ50811.1.
    RefSeqiNP_268587.1. NC_002737.1.
    YP_281556.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK33308; AAK33308; SPy_0224.
    AAZ50811; AAZ50811; M5005_Spy0192.
    GeneIDi3572737.
    900533.
    KEGGispy:SPy_0224.
    spz:M5005_Spy_0192.
    PATRICi19714248. VBIStrPyo79812_0199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33308.1 .
    CP000017 Genomic DNA. Translation: AAZ50811.1 .
    RefSeqi NP_268587.1. NC_002737.1.
    YP_281556.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali P67068.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_0224.

    Proteomic databases

    PaxDbi P67068.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK33308 ; AAK33308 ; SPy_0224 .
    AAZ50811 ; AAZ50811 ; M5005_Spy0192 .
    GeneIDi 3572737.
    900533.
    KEGGi spy:SPy_0224.
    spz:M5005_Spy_0192.
    PATRICi 19714248. VBIStrPyo79812_0199.

    Phylogenomic databases

    eggNOGi COG1210.
    HOGENOMi HOG000283477.
    KOi K00963.
    OMAi YESTHAS.
    OrthoDBi EOG6Z9B3V.

    Enzyme and pathway databases

    UniPathwayi UPA00215 .
    BioCyci SPYO160490:GJ81-211-MONOMER.
    SPYO293653:GHFC-242-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01099. galU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiHASC2_STRP1
    AccessioniPrimary (citable) accession number: P67068
    Secondary accession number(s): P58098, Q491A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3