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P67068

- HASC2_STRP1

UniProt

P67068 - HASC2_STRP1

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Protein
UTP--glucose-1-phosphate uridylyltransferase 2
Gene
hasC2, hasC.2, SPy_0224, M5005_Spy0192
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
  2. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-211-MONOMER.
SPYO293653:GHFC-242-MONOMER.
UniPathwayiUPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 2 (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
UDP-glucose pyrophosphorylase 2
Short name:
UDPGP 2
Uridine diphosphoglucose pyrophosphorylase 2
Gene namesi
Name:hasC2
Synonyms:hasC.2
Ordered Locus Names:SPy_0224, M5005_Spy0192
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299UTP--glucose-1-phosphate uridylyltransferase 2
PRO_0000201372Add
BLAST

Proteomic databases

PaxDbiP67068.

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_0224.

Structurei

3D structure databases

ProteinModelPortaliP67068.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiYESTHAS.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

P67068-1 [UniParc]FASTAAdd to Basket

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MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI    50
EEILIVTGKS KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF 100
IRQSHPRGLG DAVLQAKTFV GNEPFVVMLG DDLMDITNPN VKPLTKQLID 150
DYEETHAATI AVMRVPHEDV SNYGIIAPQA KAVKGLYSVD TFVEKPQPQD 200
APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT LNKTQRVFAR 250
EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP 299
Length:299
Mass (Da):33,302
Last modified:October 11, 2004 - v1
Checksum:iD927314E58F6091B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33308.1.
CP000017 Genomic DNA. Translation: AAZ50811.1.
RefSeqiNP_268587.1. NC_002737.1.
YP_281556.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33308; AAK33308; SPy_0224.
AAZ50811; AAZ50811; M5005_Spy0192.
GeneIDi3572737.
900533.
KEGGispy:SPy_0224.
spz:M5005_Spy_0192.
PATRICi19714248. VBIStrPyo79812_0199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33308.1 .
CP000017 Genomic DNA. Translation: AAZ50811.1 .
RefSeqi NP_268587.1. NC_002737.1.
YP_281556.1. NC_007297.1.

3D structure databases

ProteinModelPortali P67068.
ModBasei Search...

Protein-protein interaction databases

STRINGi 160490.SPy_0224.

Proteomic databases

PaxDbi P67068.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33308 ; AAK33308 ; SPy_0224 .
AAZ50811 ; AAZ50811 ; M5005_Spy0192 .
GeneIDi 3572737.
900533.
KEGGi spy:SPy_0224.
spz:M5005_Spy_0192.
PATRICi 19714248. VBIStrPyo79812_0199.

Phylogenomic databases

eggNOGi COG1210.
HOGENOMi HOG000283477.
KOi K00963.
OMAi YESTHAS.
OrthoDBi EOG6Z9B3V.

Enzyme and pathway databases

UniPathwayi UPA00215 .
BioCyci SPYO160490:GJ81-211-MONOMER.
SPYO293653:GHFC-242-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01099. galU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiHASC2_STRP1
AccessioniPrimary (citable) accession number: P67068
Secondary accession number(s): P58098, Q491A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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