P67068 (HASC2_STRP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 2
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
UDP-glucose pyrophosphorylase 2
Short name=UDPGP 2
Uridine diphosphoglucose pyrophosphorylase 2

Gene names

Name:	hasC2
Synonyms:	hasC.2
Ordered Locus Names:	SPy_0224, M5005_Spy0192

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	UTP--glucose-1-phosphate uridylyltransferase 2		PRO_0000201372

Sequences

	Sequence		Length	Mass (Da)
	P67068 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: D927314E58F6091B	FASTA	299	33,302
	10 20 30 40 50 60 MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILIVTGKS 70 80 90 100 110 120 KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF IRQSHPRGLG DAVLQAKTFV 130 140 150 160 170 180 GNEPFVVMLG DDLMDITNPN VKPLTKQLID DYEETHAATI AVMRVPHEDV SNYGIIAPQA 190 200 210 220 230 240 KAVKGLYSVD TFVEKPQPQD APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT 250 260 270 280 290 LNKTQRVFAR EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP

References

[1]

"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.

[2]

"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004092 Genomic DNA. Translation: AAK33308.1. CP000017 Genomic DNA. Translation: AAZ50811.1.
RefSeq	NP_268587.1. NC_002737.1. YP_281556.1. NC_007297.1.
3D structure databases
ProteinModelPortal	P67068.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000001473; EBSTRP00000001473; EBSTRG00000001473. EBSTRT00000028953; EBSTRP00000027971; EBSTRG00000028953.
GeneID	3572737. 900533.
GenomeReviews	Gene locus SPy_0224 in contig AE004092_GR. Gene locus M5005_Spy0192 in contig CP000017_GR.
KEGG	spy:SPy_0224. spz:M5005_Spy_0192.
PATRIC	19714248. VBIStrPyo79812_0199.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000026808.
HOGENOM	HBG688195.
OMA	HAKPWIG.
ProtClustDB	CLSK877010.
Enzyme and pathway databases
BioCyc	SPYO160490:SPY0224-MONOMER. SPYO293653:M5005_SPY0192-MONOMER.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
KO	K00963.
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. GalU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HASC2_STRP1

Accession

Primary (citable) accession number: P67068
Secondary accession number(s): P58098, Q491A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program