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Protein

Demethylmenaquinone methyltransferase

Gene

menG

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei58 – 581S-adenosyl-L-methionineUniRule annotation
Binding sitei79 – 791S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLMON169963:LMO1931-MONOMER.
UniPathwayiUPA00079; UER00169.

Names & Taxonomyi

Protein namesi
Recommended name:
Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation)
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:lmo1931
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Demethylmenaquinone methyltransferasePRO_0000193293Add
BLAST

Proteomic databases

PaxDbiP67055.

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1931.

Structurei

3D structure databases

ProteinModelPortaliP67055.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DDZ. Bacteria.
COG2226. LUCA.
HOGENOMiHOG000249463.
KOiK03183.
OMAiGGLHRAW.
OrthoDBiEOG6M6JSB.
PhylomeDBiP67055.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR014122. MenG_heptapren.
IPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02752. MenG_heptapren. 1 hit.
TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P67055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETKEEKVH KVFEKISPSY DRMNSVISFK LHVKWRKETM KLMRVQKGTN
60 70 80 90 100
VLDVCCGTAD WSIMMAEEIG PEGHVTGLDF SENMLKVGRE KVKEADLHNV
110 120 130 140 150
ELIHGNAMEL PFPDNSFDYV TIGFGLRNVP DYMQVLREMY RVLKPGGQLA
160 170 180 190 200
CIDTSQPNIP GWKQVFNAYF RYVMPVFGKF FAKSYKEYSW LQESTREFPG
210 220 230
MARLAEMFQE AGFSYVRYIS HSGGASATHF GFKKKEQ
Length:237
Mass (Da):27,330
Last modified:October 11, 2004 - v1
Checksum:i3363669F83D9AC74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591981 Genomic DNA. Translation: CAD00009.1.
PIRiAC1316.
RefSeqiNP_465455.1. NC_003210.1.
WP_003726790.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00009; CAD00009; CAD00009.
GeneIDi987989.
KEGGilmo:lmo1931.
PATRICi20313057. VBILisMon69206_1977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591981 Genomic DNA. Translation: CAD00009.1.
PIRiAC1316.
RefSeqiNP_465455.1. NC_003210.1.
WP_003726790.1. NC_003210.1.

3D structure databases

ProteinModelPortaliP67055.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo1931.

Proteomic databases

PaxDbiP67055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD00009; CAD00009; CAD00009.
GeneIDi987989.
KEGGilmo:lmo1931.
PATRICi20313057. VBILisMon69206_1977.

Phylogenomic databases

eggNOGiENOG4105DDZ. Bacteria.
COG2226. LUCA.
HOGENOMiHOG000249463.
KOiK03183.
OMAiGGLHRAW.
OrthoDBiEOG6M6JSB.
PhylomeDBiP67055.

Enzyme and pathway databases

UniPathwayiUPA00079; UER00169.
BioCyciLMON169963:LMO1931-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR014122. MenG_heptapren.
IPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02752. MenG_heptapren. 1 hit.
TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiMENG_LISMO
AccessioniPrimary (citable) accession number: P67055
Secondary accession number(s): Q92A77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.