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Protein

Demethylmenaquinone methyltransferase

Gene

menG

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58S-adenosyl-L-methionineUniRule annotation1
Binding sitei79S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processMenaquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-2063-MONOMER
UniPathwayiUPA00079; UER00169

Names & Taxonomyi

Protein namesi
Recommended name:
Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation)
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:lmo1931
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001932931 – 237Demethylmenaquinone methyltransferaseAdd BLAST237

Proteomic databases

PaxDbiP67055

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1931

Structurei

3D structure databases

ProteinModelPortaliP67055
SMRiP67055
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 107S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DDZ Bacteria
COG2226 LUCA
HOGENOMiHOG000249463
KOiK03183
OMAiVRNFENL
PhylomeDBiP67055

Family and domain databases

HAMAPiMF_01813 MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR014122 MenG_heptapren
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209 Ubie_methyltran, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02752 MenG_heptapren, 1 hit
TIGR01934 MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit
PS01184 UBIE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P67055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETKEEKVH KVFEKISPSY DRMNSVISFK LHVKWRKETM KLMRVQKGTN
60 70 80 90 100
VLDVCCGTAD WSIMMAEEIG PEGHVTGLDF SENMLKVGRE KVKEADLHNV
110 120 130 140 150
ELIHGNAMEL PFPDNSFDYV TIGFGLRNVP DYMQVLREMY RVLKPGGQLA
160 170 180 190 200
CIDTSQPNIP GWKQVFNAYF RYVMPVFGKF FAKSYKEYSW LQESTREFPG
210 220 230
MARLAEMFQE AGFSYVRYIS HSGGASATHF GFKKKEQ
Length:237
Mass (Da):27,330
Last modified:October 11, 2004 - v1
Checksum:i3363669F83D9AC74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591981 Genomic DNA Translation: CAD00009.1
PIRiAC1316
RefSeqiNP_465455.1, NC_003210.1
WP_003726790.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAD00009; CAD00009; CAD00009
GeneIDi987989
KEGGilmo:lmo1931
PATRICifig|169963.11.peg.1977

Similar proteinsi

Entry informationi

Entry nameiMENG_LISMO
AccessioniPrimary (citable) accession number: P67055
Secondary accession number(s): Q92A77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health