P67002 (TRPE_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	Mb1635

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 516	516	Anthranilate synthase component 1		PRO_0000154100

Sequences

	Sequence		Length	Mass (Da)
	P67002 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: EF19CDDE80E802C7	FASTA	516	55,849
	10 20 30 40 50 60 MHADLAATTS REDFRLLAAE HRVVPVTRKV LADSETPLSA YRKLAANRPG TFLLESAENG 70 80 90 100 110 120 RSWSRWSFIG AGAPTALTVR EGQAVWLGAV PKDAPTGGDP LRALQVTLEL LATADRQSEP 130 140 150 160 170 180 GLPPLSGGMV GFFAYDMVRR LERLPERAVD DLCLPDMLLL LATDVAAVDH HEGTITLIAN 190 200 210 220 230 240 AVNWNGTDER VDWAYDDAVA RLDVMTAALG QPLPSTVATF SRPEPRHRAQ RTVEEYGAIV 250 260 270 280 290 300 EYLVDQIAAG EAFQVVPSQR FEMDTDVDPI DVYRILRVTN PSPYMYLLQV PNSDGAVDFS 310 320 330 340 350 360 IVGSSPEALV TVHEGWATTH PIAGTRWRGR TDDEDVLLEK ELLADDKERA EHLMLVDLGR 370 380 390 400 410 420 NDLGRVCTPG TVRVEDYSHI ERYSHVMHLV STVTGKLGEG RTALDAVTAC FPAGTLSGAP 430 440 450 460 470 480 KVRAMELIEE VEKTRRGLYG GVVGYLDFAG NADFAIAIRT ALMRNGTAYV QAGGGVVADS 490 500 510 NGSYEYNEAR NKARAVLNAI AAAETLAAPG ANRSGC

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248339 Genomic DNA. Translation: CAD96303.1.
RefSeq	NP_855288.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P67002.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000016585; EBMYCP00000016420; EBMYCG00000016580.
GeneID	1092566.
GenomeReviews	Gene locus Mb1635 in contig BX248333_GR.
KEGG	mbo:Mb1635.
PATRIC	18005273. VBIMycBov88188_1784.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015088.
HOGENOM	HBG507440.
OMA	PSQRMSM.
ProtClustDB	PRK13571.
Enzyme and pathway databases
BioCyc	MBOV233413:MB1635-MONOMER.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KO	K01657.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_MYCBO

Accession

Primary (citable) accession number: P67002
Secondary accession number(s): O06127

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program