P66995 (TRPD_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate phosphoribosyltransferase
EC=2.4.2.18

Gene names

Name:	trpD
Ordered Locus Names:	NMB0967

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00211
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. HAMAP MF_00211
Sequence similarities	Belongs to the anthranilate phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Anthranilate phosphoribosyltransferase HAMAP MF_00211		PRO_0000154464

Sequences

	Sequence		Length	Mass (Da)
	P66995 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: F879D9CF8BD77563	FASTA	352	37,698
	10 20 30 40 50 60 MITPQQAIER LISNNELFYD EMTDLMRQIM RGQVLPEQIA AILTGLRIKV ETVSEITAAA 70 80 90 100 110 120 AVMREFATKV PLENAEGLVD IVGTGGDGAK TFNISTTSMF VAAAAGAKVA KHGGRSVSSS 130 140 150 160 170 180 SGAADVVEQM GANLNLTPEQ VAQSIRQTGI GFMFAPNHHS AMRHVAPVRR SLGFRSIFNI 190 200 210 220 230 240 LGPLTNPAGA PNQLLGVFHT DLCGILSRVL QQLGSKHVLV VCGEGGLDEI TLTGKTRVAE 250 260 270 280 290 300 LKDGKISEYD IRPEDFGIET RRNLDEIKVA NTQESLLKMN EVLEGREGAA RDIVLLNTAA 310 320 330 340 350 ALYAGNVAAS LSDGISAARE AIDSGRAKSK KEEFVGFQPQ QRCHFLGKME LG

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF41372.1.
PIR	A81136.
RefSeq	NP_274005.1. NC_003112.2.
3D structure databases
ProteinModelPortal	P66995.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000010598; EBNEIP00000010218; EBNEIG00000010598.
GeneID	903087.
GenomeReviews	Gene locus NMB0967 in contig AE002098_GR.
KEGG	nme:NMB0967.
PATRIC	20357423. VBINeiMen85645_1226.
TIGR	NMB0967.
Phylogenomic databases
GeneTree	EBGT00050000020527.
HOGENOM	HBG559996.
OMA	FCDIVGT.
ProtClustDB	PRK00188.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0967-MONOMER.
Family and domain databases
HAMAP	MF_00211. TrpD. [Tree]
InterPro	IPR005940. Anthranilate_Pribosyl_Tfrase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N. IPR020072. Glycosyl_Trfase_fam3_subgr_N. [Graphical view]
Gene3D	G3DSA:1.20.970.10. Glyco_trans_3. 2 hits. G3DSA:3.40.1030.10. Glyco_trans_3. 2 hits.
KO	K00766.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit.
TIGRFAMs	TIGR01245. TrpD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPD_NEIMB

Accession

Primary (citable) accession number: P66995
Secondary accession number(s): Q9JQM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program