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P66992 (TRPD_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate phosphoribosyltransferase
EC=2.4.2.18
Gene names
Name:trpD
Ordered Locus Names:Rv2192c, MT2248
ORF Names:MTCY190.03c
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00211

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. HAMAP-Rule MF_00211

Sequence similarities

Belongs to the anthranilate phosphoribosyltransferase family.

Sequence caution

The sequence AAK46534.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Anthranilate phosphoribosyltransferase HAMAP-Rule MF_00211
PRO_0000154461

Secondary structure

1 ......................................................... 370
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P66992 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 23C8B67D6C33E18D

FASTA37037,740
        10         20         30         40         50         60 
MALSAEGSSG GSRGGSPKAE AASVPSWPQI LGRLTDNRDL ARGQAAWAMD QIMTGNARPA 

        70         80         90        100        110        120 
QIAAFAVAMT MKAPTADEVG ELAGVMLSHA HPLPADTVPD DAVDVVGTGG DGVNTVNLST 

       130        140        150        160        170        180 
MAAIVVAAAG VPVVKHGNRA ASSLSGGADT LEALGVRIDL GPDLVARSLA EVGIGFCFAP 

       190        200        210        220        230        240 
RFHPSYRHAA AVRREIGVPT VFNLLGPLTN PARPRAGLIG CAFADLAEVM AGVFAARRSS 

       250        260        270        280        290        300 
VLVVHGDDGL DELTTTTTST IWRVAAGSVD KLTFDPAGFG FARAQLDQLA GGDAQANAAA 

       310        320        330        340        350        360 
VRAVLGGARG PVRDAVVLNA AGAIVAHAGL SSRAEWLPAW EEGLRRASAA IDTGAAEQLL 

       370 
ARWVRFGRQI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842579 Genomic DNA. Translation: CAA94261.1.
AE000516 Genomic DNA. Translation: AAK46534.1. Different initiation.
AL123456 Genomic DNA. Translation: CCP44969.1.
PIRA70784.
RefSeqNP_216708.1. NC_000962.3.
NP_336720.1. NC_002755.2.
YP_006515612.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZVWX-ray2.30A/B1-370[»]
2BPQX-ray1.90A/B2-370[»]
3QQSX-ray1.97A/B/C/D2-370[»]
3QR9X-ray1.87A/B2-370[»]
3QS8X-ray2.00A/B/C/D2-370[»]
3QSAX-ray2.18A/B2-370[»]
3R6CX-ray1.83A/B2-370[»]
3R88X-ray1.73A/B2-370[»]
3TWPX-ray1.83A/B/C/D2-370[»]
3UU1X-ray1.82A/B/C/D2-370[»]
ProteinModelPortalP66992.
SMRP66992. Positions 25-370.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv2192c.

Proteomic databases

PRIDEP66992.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK46534; AAK46534; MT2248.
GeneID13318881.
887681.
924178.
KEGGmtc:MT2248.
mtu:Rv2192c.
mtv:RVBD_2192c.
PATRIC18126698. VBIMycTub22151_2461.

Organism-specific databases

TubercuListRv2192c.

Phylogenomic databases

eggNOGCOG0547.
HOGENOMHOG000230451.
KOK00766.
OMAMKNVGPT.
ProtClustDBPRK00188.

Enzyme and pathway databases

UniPathwayUPA00035; UER00041.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
HAMAPMF_00211. TrpD.
InterProIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMSSF47648. Glyco_trans_3. 1 hit.
SSF52418. Glyco_trans_3. 1 hit.
TIGRFAMsTIGR01245. trpD. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP66992.

Entry information

Entry nameTRPD_MYCTU
AccessionPrimary (citable) accession number: P66992
Secondary accession number(s): L0T8W2, Q10382
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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