Reviewed, UniProtKB/Swiss-Prot P66989 (TRPC_BRUSU)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BR1141

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_0000154217

Sequences

	Sequence		Length	Mass (Da)
	P66989-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 7BDF1668C6EAEC55	FASTA	268	29,269
	10 20 30 40 50 60 MSTDILRKIE AYKREEIAAA KARLALDELK ARTRDQSAPR GFLKALEAKR AAGQFALIAE 70 80 90 100 110 120 IKKASPSKGL IRPDFDPPAL AKAYEEGGAA CLSVLTDTPS FQGAPEFLTA ARQACSLPAL 130 140 150 160 170 180 RKDFLFDPYQ VYEARSWGAD CILIIMASVD DDLAKELEDT AFALGMDALI EVHDEAEMER 190 200 210 220 230 240 ALKLSSRLLG VNNRNLRSFE VNLAVSERLA KMAPSDRLLV GESGIFTHED CLRLEKSGIG 250 260 TFLIGESLMR QHDVAAATRA LLTGAEKL

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014291 Genomic DNA. Translation: AAN30061.1.
RefSeq	NP_698146.1.
3D structure databases
HSSP	HSSP built from PDB template 1PII based on UniProtKB P00909.
ModBase	Search...
Genome annotation databases
GeneID	1166817.
GenomeReviews	Gene locus BR1141 in contig AE014291_GR.
KEGG	bms:BR1141.
TIGR	BR1141.
Phylogenomic databases
HOGENOM	P66989.
OMA	LRSPMIG.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_1141-MON.
BRENDA	4.1.1.48. 281610.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BRUSU

Accession

Primary (citable) accession number: P66989
Secondary accession number(s): Q8G0F4, Q8YHF8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)