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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Phosphoribosyl isomerase A (priA)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain (EC:4.2.1.20)
Gene namesi
Name:trpB
Ordered Locus Names:BQ2027_MB1638
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000989701 – 422Tryptophan synthase beta chainAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Structurei

3D structure databases

ProteinModelPortaliP66985
SMRiP66985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

HOGENOMiHOG000161710

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P66985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTDLSTPDL PRMSAAIAEP TSHDPDSGGH FGGPSGWGGR YVPEALMAVI
60 70 80 90 100
EEVTAAYQKE RVSQDFLDDL DRLQANYAGR PSPLYEATRL SQHAGSARIF
110 120 130 140 150
LKREDLNHTG SHKINNVLGQ ALLARRMGKT RVIAETGAGQ HGVATATACA
160 170 180 190 200
LLGLDCVIYM GGIDTARQAL NVARMRLLGA EVVAVQTGSK TLKDAINEAF
210 220 230 240 250
RDWVANADNT YYCFGTAAGP HPFPTMVRDF QRIIGMEARV QIQGQAGRLP
260 270 280 290 300
DAVVACVGGG SNAIGIFHAF LDDPGVRLVG FEAAGDGVET GRHAATFTAG
310 320 330 340 350
SPGAFHGSFS YLLQDEDGQT IESHSISAGL DYPGVGPEHA WLKEAGRVDY
360 370 380 390 400
RPITDSEAMD AFGLLCRMEG IIPAIESAHA VAGALKLGVE LGRGAVIVVN
410 420
LSGRGDKDVE TAAKWFGLLG ND
Length:422
Mass (Da):44,645
Last modified:October 11, 2004 - v1
Checksum:i7976DA2DC85D5E78
GO

Sequence cautioni

The sequence SIU00242 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU00242.1 Different initiation.
RefSeqiNP_855291.1, NC_002945.3

Genome annotation databases

EnsemblBacteriaiCDO42887; CDO42887; Mb1638
PATRICifig|233413.5.peg.1787

Similar proteinsi

Entry informationi

Entry nameiTRPB_MYCBO
AccessioniPrimary (citable) accession number: P66985
Secondary accession number(s): A0A1R3XYT6, O08376, X2BI05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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