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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Phosphoribosyl isomerase A (priA)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei57Proton acceptorUniRule annotation1
Active sitei68Proton acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-1697-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotation
Ordered Locus Names:BQ2027_MB1639
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000988121 – 270Tryptophan synthase alpha chainAdd BLAST270

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP66981
SMRiP66981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223815
OMAiDYPPEEC

Family and domain databases

CDDicd04724 Tryptophan_synthase_alpha, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00131 Trp_synth_alpha, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011060 RibuloseP-bd_barrel
IPR018204 Trp_synthase_alpha_AS
IPR002028 Trp_synthase_suA
PfamiView protein in Pfam
PF00290 Trp_syntA, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00262 trpA, 1 hit
PROSITEiView protein in PROSITE
PS00167 TRP_SYNTHASE_ALPHA, 1 hit

Sequencei

Sequence statusi: Complete.

P66981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVEQSEAS RLGPVFDSCR ANNRAALIGY LPTGYPDVPA SVAAMTALVE
60 70 80 90 100
SGCDIIEVGV PYSDPGMDGP TIARATEAAL RGGVRVRDTL AAVEAISIAG
110 120 130 140 150
GRAVVMTYWN PVLRYGVDAF ARDLAAAGGL GLITPDLIPD EAQQWLAASE
160 170 180 190 200
EHRLDRIFLV APSSTPERLA ATVEASRGFV YAASTMGVTG ARDAVSQAAP
210 220 230 240 250
ELVGRVKAVS DIPVGVGLGV RSRAQAAQIA QYADGVIVGS ALVTALTEGL
260 270
PRLRALTGEL AAGVRLGMSA
Length:270
Mass (Da):27,728
Last modified:October 11, 2004 - v1
Checksum:i9B55994F704A9C76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU00243.1
RefSeqiNP_855292.1, NC_002945.3
WP_003407999.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42888; CDO42888; Mb1639
PATRICifig|233413.5.peg.1788

Similar proteinsi

Entry informationi

Entry nameiTRPA_MYCBO
AccessioniPrimary (citable) accession number: P66981
Secondary accession number(s): A0A1R3Y0Y5, O06130, X2BIP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health