Reviewed, UniProtKB/Swiss-Prot P66956 (TALB_SALTI)

Names and origin

Protein names

Recommended name:
    Transaldolase B
    EC=2.2.1.2

Gene names

Name:	talB
Ordered Locus Names:	STY0007, t0007

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway By similarity.
Catalytic activity	Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. HAMAP MF_00492
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. HAMAP MF_00492
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the transaldolase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pentose shunt
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transaldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 317	316	Transaldolase B HAMAP MF_00492		PRO_0000173614
Sites
	Active site	132	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P66956-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 620095E5BD30F42C	FASTA	317	35,171
	10 20 30 40 50 60 MTDKLTSLRQ FTTVVADTGD IAAMKLYQPQ DATTNPSLIL NAAQIPEYRK LIDDAVAWAK 70 80 90 100 110 120 QQSSDRAQQV VDATDKLAVN IGLEILKLVP GRISTEVDAR LSYDTEASIA KAKRIIKLYN 130 140 150 160 170 180 DAGISNDRIL IKLASTWQGI RAAEQLEKEG INCNLTLLFS FAQARACAEA GVYLISPFVG 190 200 210 220 230 240 RILDWYKANT DKKDYAPAED PGVVSVTEIY EYYKQHGYET VVMGASFRNV GEILELAGCD 250 260 270 280 290 300 RLTIAPALLK ELAESEGAIE RKLSFSGEVK ARPERITEAE FLWQHHQDPM AVDKLADGIR 310 KFAVDQEKLE KMIGDLL

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL627265 Genomic DNA. Translation: CAD01160.1. AE014613 Genomic DNA. Translation: AAO67741.1.
RefSeq	NP_454617.1. NP_803892.1.
3D structure databases
HSSP	HSSP built from PDB template 1ONR based on UniProtKB P30148.
SMR	P66956. Positions 2-317.
ModBase	Search...
Proteomic databases
PRIDE	P66956.
Genome annotation databases
GeneID	1067000. 1246518.
GenomeReviews	Gene locus t0007 in contig AE014613_GR. Gene locus STY0007 in contig AL513382_GR.
KEGG	stt:t0007. sty:STY0007.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P66956.
OMA	EYKPQDA.
Enzyme and pathway databases
BioCyc	SENT209261:T0007-MON. SENT220341:STY0007-MON.
BRENDA	2.2.1.2. 3716.
Family and domain databases
HAMAP	MF_00492. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001585. Transaldolase. IPR004730. Transaldolase_AB. IPR018225. Transaldolase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10683. Transaldolase. 1 hit. PTHR10683:SF3. Transaldolase_AB. 1 hit.
Pfam	PF00923. Transaldolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00874. talAB. 1 hit.
PROSITE	PS01054. TRANSALDOLASE_1. 1 hit. PS00958. TRANSALDOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TALB_SALTI

Accession

Primary (citable) accession number: P66956
Secondary accession number(s): Q8XG45

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)