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P66946 (ILVG_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative acetolactate synthase large subunit IlvG
Short name=ALS
EC=2.2.1.6
Alternative name(s):
Acetohydroxy-acid synthase large subunit
Short name=AHAS
Gene names
Name:ilvG
Ordered Locus Names:Rv1820, MT1868
ORF Names:MTCY1A11.23c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine By similarity.

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Subunit structure

Heterodimer of large catalytic subunit and small regulatory subunit By similarity.

Sequence similarities

Belongs to the TPP enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547Putative acetolactate synthase large subunit IlvG
PRO_0000090805

Regions

Nucleotide binding299 – 31820FAD By similarity
Region388 – 46881Thiamine pyrophosphate binding

Sites

Metal binding4391Magnesium By similarity
Metal binding4661Magnesium By similarity
Binding site571Thiamine pyrophosphate By similarity
Binding site1591FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P66946 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 2D5CC10B21406887

FASTA54757,521
        10         20         30         40         50         60 
MSTDTAPAQT MHAGRLIARR LKASGIDTVF TLSGGHLFSI YDGCREEGIR LIDTRHEQTA 

        70         80         90        100        110        120 
AFAAEGWSKV TRVPGVAALT AGPGITNGMS AMAAAQQNQS PLVVLGGRAP ALRWGMGSLQ 

       130        140        150        160        170        180 
EIDHVPFVAP VARFAATAQS AENAGLLVDQ ALQAAVSAPS GVAFVDFPMD HAFSMSSDNG 

       190        200        210        220        230        240 
RPGALTELPA GPTPAGDALD RAAGLLSTAQ RPVIMAGTNV WWGHAEAALL RLVEERHIPV 

       250        260        270        280        290        300 
LMNGMARGVV PADHRLAFSR ARSKALGEAD VALIVGVPMD FRLGFGGVFG STTQLIVADR 

       310        320        330        340        350        360 
VEPAREHPRP VAAGLYGDLT ATLSALAGSG GTDHQGWIEE LATAETMARD LEKAELVDDR 

       370        380        390        400        410        420 
IPLHPMRVYA ELAALLERDA LVVIDAGDFG SYAGRMIDSY LPGCWLDSGP FGCLGSGPGY 

       430        440        450        460        470        480 
ALAAKLARPQ RQVVLLQGDG AFGFSGMEWD TLVRHNVAVV SVIGNNGIWG LEKHPMEALY 

       490        500        510        520        530        540 
GYSVVAELRP GTRYDEVVRA LGGHGELVSV PAELRPALER AFASGLPAVV NVLTDPSVAY 


PRRSNLA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842577 Genomic DNA. Translation: CAB01459.1.
AE000516 Genomic DNA. Translation: AAK46141.1.
PIRE70720.
RefSeqNP_216336.1. NC_000962.2.
NP_336327.1. NC_002755.2.

3D structure databases

ProteinModelPortalP66946.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002093; EBMYCP00000002093; EBMYCG00000002091.
EBMYCT00000069423; EBMYCP00000067482; EBMYCG00000069418.
GeneID885738.
923757.
GenomeReviewsGene locus MT1868 in contig AE000516_GR.
Gene locus Rv1820 in contig AL123456_GR.
KEGGmtc:MT1868.
mtu:Rv1820.
PATRIC18125879. VBIMycTub22151_2052.
TIGRMT1868.

Organism-specific databases

TubercuListRv1820.

Phylogenomic databases

GeneTreeEBGT00050000014643.
HOGENOMHBG323037.
OMAQSWIREL.
PhylomeDBP66946.
ProtClustDBPRK05858.

Family and domain databases

InterProIPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
KOK01652.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PROSITEPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVG_MYCTU
AccessionPrimary (citable) accession number: P66946
Secondary accession number(s): Q50613
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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