Reviewed,
UniProtKB/Swiss-Prot P66927 (THIL_MYCBO)
Last modified
November 3, 2009.
Version 28.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Probable acetyl-CoA acetyltransferase EC=2.3.1.9 Alternative name(s): Acetoacetyl-CoA thiolase | ||||
| Gene names |
| ||||
| Organism | Mycobacterium bovis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1765 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 389 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 2 acetyl-CoA = CoA + acetoacetyl-CoA. |
| Sequence similarities | Belongs to the thiolase family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | acetyl-CoA C-acetyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 389 | 389 | Probable acetyl-CoA acetyltransferase | PRO_0000206459 | |||||
Sites | |||||||||
| Active site | 84 | 1 | Acyl-thioester intermediate By similarity | ||||||
| Active site | 345 | 1 | Proton acceptor By similarity | ||||||
| Active site | 375 | 1 | Proton acceptor By similarity | ||||||
Sequences
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References
| [1] | "The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. Hewinson R.G.Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97. |
Cross-references
Sequence databases | |
|---|---|
| BX248338 Genomic DNA. Translation: CAD94219.1. | |
| RefSeq | NP_855012.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1PXT based on UniProtKB P27796. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1090649. |
| GenomeReviews | Gene locus Mb1358 in contig BX248333_GR. |
| KEGG | mbo:Mb1358. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P66927. |
| OMA | DANTHDG. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.9. 3091. |
Family and domain databases | |
| InterPro | IPR002155. Thiolase. IPR016038. Thiolase-like_subgr. [Graphical view] |
| Gene3D | G3DSA:3.40.47.10. Thiolase-like_subgr. 1 hit. |
| PANTHER | PTHR18919. Thiolase. 1 hit. |
| Pfam | PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000429. Ac-CoA_Ac_transf. 1 hit. |
| TIGRFAMs | TIGR01930. AcCoA-C-Actrans. 1 hit. |
| PROSITE | PS00098. THIOLASE_1. 1 hit. PS00737. THIOLASE_2. 1 hit. PS00099. THIOLASE_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | THIL_MYCBO | ||||||||
| Accession | Primary (citable) accession number: P66927 Secondary accession number(s): Q10629 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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