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P66922

- THIM_STAAM

UniProt

P66922 - THIM_STAAM

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, SAV2092
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate; via amide nitrogen By similarity
Binding sitei115 – 1151ATP By similarity
Binding sitei160 – 1601ATP By similarity
Binding sitei187 – 1871Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2152-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:SAV2092
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Hydroxyethylthiazole kinaseUniRule annotation
PRO_0000156953Add
BLAST

Proteomic databases

PRIDEiP66922.

2D gel databases

World-2DPAGE0002:P66922.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2092.

Structurei

3D structure databases

ProteinModelPortaliP66922.
SMRiP66922. Positions 4-262.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.
PhylomeDBiP66922.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

P66922-1 [UniParc]FASTAAdd to Basket

« Hide

MNYLNKIRIE NPLTICYTND VVKNFTANGL LSIGASPAMS EAPEEAEEFY    50
KVAQALLINI GTLTAQNEQD IIAIAQTANE AGLPIVFDPV AVGASTYRKQ 100
FCKLLLKSAK VSVIKGNASE ILALIDDTAT MKGTDSDANL DAVAIAKKAY 150
AIYKTAIVIT GKEDVIVQDN KAIVLANGSP LLARVTGAGC LLGGVIAGFL 200
FRETEPDIEA LIEAVSVFNI AAEVAAENEN CGGPGTFSPL LLDTLYHLNE 250
TTYQQRIRIQ EVE 263
Length:263
Mass (Da):28,067
Last modified:October 11, 2004 - v1
Checksum:iB7D8DD02F2D8E98E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58254.1.
RefSeqiNP_372616.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58254; BAB58254; SAV2092.
GeneIDi1122109.
KEGGisav:SAV2092.
PATRICi19565062. VBIStaAur52173_2166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58254.1 .
RefSeqi NP_372616.1. NC_002758.2.

3D structure databases

ProteinModelPortali P66922.
SMRi P66922. Positions 4-262.
ModBasei Search...

Protein-protein interaction databases

STRINGi 158878.SAV2092.

2D gel databases

World-2DPAGE 0002:P66922.

Proteomic databases

PRIDEi P66922.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB58254 ; BAB58254 ; SAV2092 .
GeneIDi 1122109.
KEGGi sav:SAV2092.
PATRICi 19565062. VBIStaAur52173_2166.

Phylogenomic databases

eggNOGi COG2145.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.
PhylomeDBi P66922.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci SAUR158878:GJJ5-2152-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiTHIM_STAAM
AccessioniPrimary (citable) accession number: P66922
Secondary accession number(s): Q99SG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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