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P66915 (THID_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:SAV2093
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192028

Sites

Binding site451Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P66915 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 4E42A1E6A6622004

FASTA27630,242
        10         20         30         40         50         60 
MIKPKIALTI AGTDPTGGAG VMADLKSFHS CGVYGMGVVT SIVAQNTLGV QHIHNLNHQW 

        70         80         90        100        110        120 
VDEQLDSVFN DTLPHAIKTG MIATADTMET IRHYLMQHES IPYVIDPVML AKSGDSLMDN 

       130        140        150        160        170        180 
DTKQNLQHTL LPLADVVTPN LPEAEEITGL TIDSEEKIMQ AGRIFINEIG SKGIIIKGGH 

       190        200        210        220        230        240 
SNDTDIAKDY LFTNEGVQTF ENERFKTKHT HGTGCTFSAV ITAELAKGRP LFEAVHKAKK 

       250        260        270 
FISMSIQYTP EIGRGRGPVN HFAYLKKEGL DDELSK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000017 Genomic DNA. Translation: BAB58255.1.
RefSeqNP_372617.1. NC_002758.2.

3D structure databases

ProteinModelPortalP66915.
SMRP66915. Positions 5-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING158878.SAV2093.

2D gel databases

World-2DPAGE0002:P66915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB58255; BAB58255; SAV2093.
GeneID1122110.
KEGGsav:SAV2093.
PATRIC19565064. VBIStaAur52173_2167.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0351.
KOK00941.
OMATNHWAYS.
OrthoDBEOG6XWV53.
PhylomeDBP66915.

Enzyme and pathway databases

BioCycSAUR158878:GJJ5-2153-MONOMER.
UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_STAAM
AccessionPrimary (citable) accession number: P66915
Secondary accession number(s): Q99SG4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways