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P66914 (THID_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:Mb0430c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192024

Sites

Binding site441Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P66914 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 143ADA6070BEE2C4

FASTA26527,511
        10         20         30         40         50         60 
MTPPRVLSIA GSDSGGGAGI QADMRTMALL GVHACVAVTA VTVQNTLGVK DIHEVPNDVV 

        70         80         90        100        110        120 
AGQIEAVVTD IGVQAAKTGM LASSRIVATV AATWRRLELS VPLVVDPVCA SMHGDPLLAP 

       130        140        150        160        170        180 
SALDSLRGQL FPLATLLTPN LDEARLLVDI EVVDAESQRA AAKALHALGP QWVLVKGGHL 

       190        200        210        220        230        240 
RSSDGSCDLL YDGVSCYQFD AQRLPTGDDH GGGDTLATAI AAALAHGFTV PDAVDFGKRW 

       250        260 
VTECLRAAYP LGRGHGPVSP LFRLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248335 Genomic DNA. Translation: CAD93293.1.
RefSeqNP_854093.1. NC_002945.3.

3D structure databases

ProteinModelPortalP66914.
SMRP66914. Positions 4-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb0430c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD93293; CAD93293; Mb0430c.
GeneID1091436.
KEGGmbo:Mb0430c.
PATRIC18002601. VBIMycBov88188_0469.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0351.
HOGENOMHOG000225275.
KOK00941.
OMAFAFHCVH.
OrthoDBEOG6XWV53.
ProtClustDBPRK06427.

Enzyme and pathway databases

UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_MYCBO
AccessionPrimary (citable) accession number: P66914
Secondary accession number(s): P96268
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways